Detection of pathogenic activity of the autoantibodies in SLE and antiphospholipid syndrome
| Project/Area Number |
24590681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUBOTA Tetsuo 東京医科歯科大学, 大学院保健衛生学研究科, 教授 (90205138)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 全身性エリテマトーデス / 抗リン脂質抗体症候群 / 抗DNA抗体 / 抗リン脂質抗体 / 膠原病 / 自己抗体 |
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| Outline of Final Research Achievements |
The final goal of this study is selective detection of pathogenic autoantibodies in systemic lupus erythematosus and/or antiphospholipid syndrome. For the first step, we studied whether anti-DNA and antiphospholipid antibodies have activities to induce expression of specific molecules which have been suggested to play a role in the pathogenesis.
Some antibodies cross-reactive with DNA and phospholipid induced expression of tissue factor in monocytes, and BAFF or IL-1β in macrophage-like cells, suggesting that these antoantibodies have pathogenic activities.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes.2014
Author(s)
Nakagawa K, Kawai T, Umebayashi H, Takei S, Kobayashi N, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI et al.
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Journal Title
Ann Rheum Dis.
Volume: in press
Issue: 3
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity.2012
Author(s)
Suzuki F, Kubota T, Miyazaki Y, Ishikawa K, Ebisawa M, Hirohata S, Ogura T, Mizusawa H, Imai T, Miyasaka N, Nanki T.
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Journal Title
Arthritis Research and Therapy
Volume: 14
Related Report
Peer Reviewed
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