| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The final goal of this study is selective detection of pathogenic autoantibodies in systemic lupus erythematosus and/or antiphospholipid syndrome. For the first step, we studied whether anti-DNA and antiphospholipid antibodies have activities to induce expression of specific molecules which have been suggested to play a role in the pathogenesis.
Some antibodies cross-reactive with DNA and phospholipid induced expression of tissue factor in monocytes, and BAFF or IL-1β in macrophage-like cells, suggesting that these antoantibodies have pathogenic activities.
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