| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Plasma cholesteryl ester transfer protein (CETP) deficiency is autosomal recessive (in part, co-dominant) disease/trait manifesting increased HDL-CE because the deficiency of CE transfer between VLDL or LDL and HDL. HDL2, large HDL found in CETP deficiency is reported to have decreased sphingomyelin levels. In this study, SM and apoE as well as apoC-I were determined in subjects with CETP deficiency. Isolation of HDL was done by ultracentrifugation or PEG precipitation. CETP deficiency may have increased SM and CE in HDL2, some of large HDL is so buoyant as to be found in the LDL fraction.
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