The impact of genetic variants of heme oxygenase-1 on transplant outcomes after unrelated bone marrow transplantation and development of new treatment strategy
| Project/Area Number |
24590684
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAMI Akiyoshi 愛知医科大学, 医学部, 教授 (80324078)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ヘムオキシゲナーゼ-1 / 骨髄移植 / 血管内皮細胞傷害 / トロンボモジュリン / 組織因子 / 急性GVHD / 一塩基多型 / 血管内皮細胞 / IL-6 / ICAM-1 / 幹細胞移植後合併症 / ヘムオキシゲナーゼー１ / 放射線障害 / 一塩基置換（SNP) / 同種骨髄移植 / 移植関連合併症 |
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| Outline of Final Research Achievements |
We revealed that the THBD gene single nucleotide variation rs3176123 in the donor side influences a risk for acute graft-versus-host disease (GVHD) and the subsequent mortality after unrelated bone marrow transplantation. We also demonstrated that exposure of radiation on human umbilical vein endothelial cells resulted in significant increases in tissue factor (TF), IL-6, and ICAM-1 mRNA expressions. On the other hand, thrombomodulin (TM) mRNA expression was significantly decreased. Pretreatment of recombinant TM inhibited radiation-induced expression of TF. Recombinant TM would be effective for the prevention of transplant-related complications.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] Late onset thrombosis in two Japanese patients with compound heterozygote protein S deficiency.2015
Author(s)
Taniguchi F, Morishita E, Sekiya A, Yamaguchi D, Nomoto H, Kobayashi E, Takata M, Kosugi I, Takeuchi N, Asakura H, Ohtake S.
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Journal Title
Thromb Res
Volume: in press
Issue: 6
Pages: 1221-1223
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Antithrombin deficiency in three Japanese families: one novel and two reported point mutations in the antithrombin gene.2013
Author(s)
Maruyama K, Morishita E, Karato M, Kadono T, Sekiya A, Goto Y, Sato T, Nomoto H, Omi W, Tsuzura S, Imai H, Asakura H, Ohtake S, Nakao S.
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Journal Title
Thromb Res
Volume: 132
Issue: 2
Pages: e118-e123
DOI
Related Report
Peer Reviewed
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[Journal Article] Plasma levels of platelet-derived microparticles in patients with obstructive sleep apnea syndrome2012
Author(s)
Maruyama K, Morishita E, Sekiya A, Omote M, Kadono T, Asakura H, Hashimoto M, Kobayashi M, Nakatsumi Y, Takada S, Ohtake S
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Journal Title
J Atheroscler Thromb
Volume: 19
Pages: 98-104
NAID
Related Report
Peer Reviewed
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[Journal Article] Late response to low-dose imatinib in patients with chronic phase chronic myeloid leukemia2012
Author(s)
Takami A, Ohtake S, Morishita E, Terasaki Y, Fukushima T, Kurokawa T, Sugimori N, Matano S, Ohata K, Saito C, Yamaguchi M, Hosokawa K, Yamazaki H, Kondo Y, Nakao S
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Journal Title
Int J Hematol
Volume: 96
Issue: 3
Pages: 357-363
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] 血栓性素因の診断2015
Author(s)
森下英理子
Organizer
第28回有明セミナー
Place of Presentation
TOC有明イーストタワー（東京都江東区）
Year and Date
2015-03-14
Related Report
Invited
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[Presentation] Thrombomodulin has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies2014
Author(s)
Nomoto H, Morishita E, Takami A, Katsu S, Yamaguchi D, Yasuo Morishima M, Onizuka M, Kashiwase K, Fukuda T, Kodera Y, Suzuki Y, Nitta N, Nakao S, Ohtake S
Organizer
56th American Society of Hematology Annual Meeting
Place of Presentation
Moscone Center (San Francisco, USA)
Year and Date
2014-12-05 – 2014-12-09
Related Report
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