| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We revealed that the THBD gene single nucleotide variation rs3176123 in the donor side influences a risk for acute graft-versus-host disease (GVHD) and the subsequent mortality after unrelated bone marrow transplantation. We also demonstrated that exposure of radiation on human umbilical vein endothelial cells resulted in significant increases in tissue factor (TF), IL-6, and ICAM-1 mRNA expressions. On the other hand, thrombomodulin (TM) mRNA expression was significantly decreased. Pretreatment of recombinant TM inhibited radiation-induced expression of TF. Recombinant TM would be effective for the prevention of transplant-related complications.
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