Clarification of the involvement of leptin and ghrelin in cardiovascular dysautonomia and vision for treatment in Parkinson disease.

• Project/Area Number: 24590691
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Nagoya University
• Principal Investigator: NAKAMURA TOMOHIKO 名古屋大学, 医学部附属病院, 助教 (00437039)
• Co-Investigator(Kenkyū-buntansha): WATANABE Horohisa 名古屋大学, 脳とこころの研究センター, 特任教授 (10378177) ; HIRAYAMA Masaaki 名古屋大学, 医学系研究科, 准教授 (30283435) ; SOBUE Gen 名古屋大学, 医学系研究科, 教授 (20148315)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: パーキンソン病 / 起立性低血圧 / 食事性低血圧 / グレリン / レプチン / 自律神経障害

Outline of Final Research Achievements

We evaluated the involvement of leptin and ghrelin in patients with Parkinson's disease. Decrease in systolic blood pressure during the head-up tilt test was associated with low concentration of basic value of leptin and high concentration of basic value of active ghrelin. Decreased activity of sympathetic nerves and vasodilating effects caused by low concentration of leptin and high concentration of active ghrelin may associates with orthostatic hypotension in Parkinson's disease.
Decrease in systolic blood pressure after glucose load was tend to be associated with percentage change of active ghrelin of the glucose load. Ghrelin is appetite stimulant hormone and is considered to decrease after glucose load. But in Parkinson's disease patients’s with postprandial hypotension, this response is impaired and may result in vasodilation.

Research Products

• [Presentation] Leptin and ghrelin concentrations and cardiovascular dysautonomia in Parkinson’s disease (2014)
  • Author(s): Tomohiko Nakamura, Suzuki Masashi, Akinori Okada, Junichiro Suzuki, Sarotu Hasegawa, Masaaki Hirayama, Gen Sobue
  • Organizer: 4th Asian and Oceanian Parkinson's Disease and Movement Disorders Congress
  • Place of Presentation: Pattaya, Thailand,at the Pattaya Exhibition and Conventon Hall
  • Year and Date: 2014-11-28 – 2014-11-30
• [Presentation] パーキンソン病の心血管系自律神経障害におけるグレリン、レプチンの関与の検討 (2014)
  • Author(s): 中村 友彦 ,鈴木 将史 ,岡田 暁典 ,鈴木 淳一郎 ,長谷川 聖 ,平山 正昭 ,祖父江 元
  • Organizer: 第８回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都府京都市(京都ホテルオークラ)
  • Year and Date: 2014-10-02 – 2014-10-04
• [Presentation] Leptin and ghrelin concentrations and cardiovascular dysautonomia in Parkinson’s disease (2014)
  • Author(s): Tomohiko Nakamura, Yui Okada, Akinori Okada, Junichiro Suzuki, Yasuaki Mizutani, Masaaki Hirayama, Gen Sobue
  • Organizer: 18th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Stockholm, Sweden,Stockholmsmassen (Stockholm Convention Centre)
  • Year and Date: 2014-06-08 – 2014-06-12
• [Presentation] Leptin and ghrelin concentrations and cardiovascular dysautonomia in Parkinson’s disease (2014)
  • Author(s): Tomohiko Nakamura, Yui Okada, Akinori Okada, Junichiro Suzuki, Yasuaki Mizutani, Masaaki Hirayama, Gen Sobue
  • Organizer: 18TH INTERNATIONAL CONGRESS OF PARKINSON'S DISEASE AND MOVEMENT DISORDERS
  • Place of Presentation: Stockholm, Sweden
• [Presentation] パーキンソン病の心血管系自律神経障害におけるグレリン、レプチンの関与の検討 (2013)
  • Author(s): 中村友彦 岡田ゆい 岡田暁典 鈴木淳一郎 水谷泰彰 平山正昭 祖父江元
  • Organizer: 第7回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京王プラザホテル（東京都 新宿区）