• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pharmacogenomics using DNA Microarray in the treatment of type 2 diabetes

Research Project

Project/Area Number 24590693
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionMie University

Principal Investigator

NAKATANI KANAME  三重大学, 医学部附属病院, 准教授 (80237304)

Co-Investigator(Kenkyū-buntansha) MOCHIKI Ikuyo  三重大学, 医学部, 講師 (20369614)
NOBORI Tsutomu  三重大学, 医学(系)研究科, 特任教授 (60106995)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsファーマコゲノミクス / 2型糖尿病 / 薬剤トランスポーター / DNAマイクロアレイ / 糖尿病治療
Outline of Final Research Achievements

Personalized medicine based on pharmacogenomics is being developed at the clinical stage. These developments in personalized medicine are strongly supported by marked innovations in genetic analyses. However, there are currently no potential companion diagnostics for common diseases. As common diseases are multifactorial, we appreciated that drugs pass through complex metabolic pathways was important rather than experience a single enzymatic modification to predict therapeutic efficacy.
We attempted DNA microarray system in type 2 diabetes mellitus (T2DM). Sitagliptin is most popular DPP4-i, but showed individual response variability. We designed a study to develop personalized medicine of T2DM by sitagliptin based on drug metabolism. Sitagliptin is excreted through kidney and pharmacokinetics is mostly regulated by P-glycoprotein (ABCB1) and organic anion transport (OAT3). We analyzed multiple genetic variants determined by the DMET including ABCB1 and OAT3 in T2DM patients.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 Other

All Journal Article (17 results) (of which Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (8 results) (of which Invited: 8 results)

  • [Journal Article] Bilateral giant coronary aneurysms in a 40-year-old male with Noonan syndrome caused by a KRAS germline mutation.2014

    • Author(s)
      Fujimoto N, Nakajima H, Sugiura E, Dohi K, Kanemitsu S, Yamada N, Aoki Y, Nakatani K, Shimpo H, Nobori T, Ito M
    • Journal Title

      Int J Cadiol

      Volume: 173 Issue: 3 Pages: e63-e66

    • DOI

      10.1016/j.ijcard.2014.03.135

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 遺伝子解析による体質診断の科学的評価2014

    • Author(s)
      中谷 中
    • Journal Title

      Bio Clinica

      Volume: 29 Pages: 100-103

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] 診療における遺伝情報の取り扱いについて2014

    • Author(s)
      中谷 中
    • Journal Title

      臨床病理

      Volume: 62 Pages: 1122-1127

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] アカデミアにおけるバイオマーカー検査2014

    • Author(s)
      中谷 中
    • Journal Title

      臨床病理レビュー

      Volume: 153 Pages: 71-75

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] コンパニオン診断の実践に求められる検査体制2014

    • Author(s)
      中谷 中
    • Journal Title

      臨床検査

      Volume: 58 Pages: 933-938

    • Related Report
      2014 Annual Research Report
    • Open Access
  • [Journal Article] Posterior-predominant leukoencephalopathy which was caused by methylenetetrahydrofolate reductase deficiency and successfully treated with folic acid.2014

    • Author(s)
      Tamura A, Sasaki R, Kagawa K, Nakatani K, Osaka H, Tomimoto H.
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 54 Pages: 200-206

    • NAID

      130004505567

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immune response following liver transplantation compared to kidney transplantation: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity and cytochrome P450 3A5 genotype assay.2013

    • Author(s)
      Nobuoka Y, Mizuno S, Nishikawa K, Nakatani K, Muraki Y, Yamada T, Okuda M, Nobori T, Sugimura Y, Isaji S.
    • Journal Title

      Clin Dev Immunol

      Volume: - Pages: 1-8

    • DOI

      10.1155/2013/936063

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunological aspects in late phase of living donor liver transplant patients: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity.2013

    • Author(s)
      Mizuno S, Muraki Y, Nakatani K, Tanemura A, Kuriyama N, Ohsawa I, Azumi Y, Kishiwada M, Usui M, Sakurai H, Tabata M, Yamamoto N, Yamada T, Shiraki K, Takei Y, Nobori T, Okuda M, Isaji S.
    • Journal Title

      Clin Dev Immunol

      Volume: - Pages: 1-8

    • DOI

      10.1155/2013/982163

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combination assays for evaluation of immune function and CYP3A5 genotype to identify the risk of infectious complications and mortality in living donor liver transplant patients.2013

    • Author(s)
      Mizuno S, Nakatani K, Muraki Y, Tanemura A, Azumi Y, Kuriyama N, Ohsawa I, Kishiwada M, Usui M, Sakurai H, Tabata M, Okuda M, Nobori T, Isaji S.
    • Journal Title

      Ann Transplant

      Volume: 18 Pages: 349-357

    • DOI

      10.12659/aot.883974

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kidney-protective effects of azelnidipine versus a diuretic in combination with olmesartan in hypertensive patients with diabetes and albuminuria: a randomized study.2013

    • Author(s)
      Kojima M, Okubo S, Mizubayashi R, Isaka N, Machida H, Okamoto S, Hirota H, Takeuchi M, Kato T, Nakatani K, Mizuno O, Miyagawa K, Makino K, Okura T, Dohi Y, Ito M, Kimura G.
    • Journal Title

      Nephrol Dial Transplant

      Volume: - Issue: 7 Pages: 1802-1810

    • DOI

      10.1093/ndt/gft034

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between CYP2C19 loss-of-function polymorphism and platelet reactivities with clopidogrel treatment in Japanese patients undergoing coronary stent implantation.2013

    • Author(s)
      Nakata T, Miyahara M, Nakatani K, Wada H, Tanigawa T, Komada F, Hoshino K, Aoki T, Nishimura Y, Tamaru S, Ito M, Nishikawa M; McLordd Group.
    • Journal Title

      Circ J

      Volume: 77 Pages: 1436-1444

    • NAID

      10031158872

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 分子疫学解析に利用される遺伝子検査-ヒト編-ファーマコゲノミクス2013

    • Author(s)
      中谷 中、登 勉
    • Journal Title

      臨床病理

      Volume: 61 Pages: 1018-1025

    • Related Report
      2013 Research-status Report
  • [Journal Article] オーダーメイド医療と臨床検査2013

    • Author(s)
      中谷 中
    • Journal Title

      日本内科学会誌

      Volume: 102 Pages: 3103-3109

    • Related Report
      2013 Research-status Report
  • [Journal Article] 「遺伝子検査の標準化に向けて」ウイルス感染症関連検査2013

    • Author(s)
      中谷 中
    • Journal Title

      臨床検査

      Volume: 57 Pages: 726-730

    • Related Report
      2013 Research-status Report
  • [Journal Article] 「個別化医療と臨床検査 新しいバイオマーカーとしてのPharmacogenomics: PGx」移植医療におけるオーダーメイド医療2013

    • Author(s)
      中谷 中
    • Journal Title

      臨床病理

      Volume: 61 Pages: 428-433

    • Related Report
      2013 Research-status Report
  • [Journal Article] 「個別化医療推進に向けたコンパニオン診断法の役割と期待」個別化医療の実施に向けた医療機関での検査体制作り2013

    • Author(s)
      中谷 中
    • Journal Title

      日本臨床検査自動化学会会誌

      Volume: 38 Pages: 169-172

    • Related Report
      2013 Research-status Report
  • [Journal Article] アカデミアにおける個別化医療の推進2013

    • Author(s)
      中谷 中
    • Journal Title

      腫瘍内科

      Volume: 11 Pages: 640-643

    • Related Report
      2013 Research-status Report
  • [Presentation] ゲノム解析技術の検査医学研究への応用2014

    • Author(s)
      中谷 中、登 勉
    • Organizer
      第25回日本臨床化学会東海・北陸支部総会
    • Place of Presentation
      名古屋大学医学部
    • Year and Date
      2014-08-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Pharmacogenomics using DNA microarray2014

    • Author(s)
      Kaname Nakatani
    • Organizer
      The 9th International Conference of Clinical Laboratory Automation and Robotics,
    • Place of Presentation
      Yokohama Red Brik Warehouse
    • Year and Date
      2014-04-18 – 2014-04-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Potential personalized medicine in common disease2014

    • Author(s)
      Kaname Nakatani
    • Organizer
      The 9th International Conference of Clinical Laboratory Automation & Robotics
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 「遺伝子解析研究の進歩と臨床検査への応用」 ファーマコゲノミクスの臨床応用2013

    • Author(s)
      中谷 中
    • Organizer
      第53回日本臨床化学会年次学術集会
    • Place of Presentation
      徳島
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] アカデミアにおけるファーマコゲノミクスの現状と可能性2013

    • Author(s)
      中谷 中
    • Organizer
      第23回日本医療薬学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Invited
  • [Presentation] 薬物代謝酵素/トランスポーター遺伝子解析用マイクロアレイの有用性と実臨床への応用2013

    • Author(s)
      中谷 中
    • Organizer
      第20回遺伝子診療学会大会
    • Place of Presentation
      浜松
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ファーマコゲノミクスの臨床応用2013

    • Author(s)
      中谷 中
    • Organizer
      第53回日本臨床化学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ゲノム解析技術の検査医学研究への応用

    • Author(s)
      中谷 中
    • Organizer
      第25回日本臨床化学会東海・北陸支部総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
    • Invited

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi