Pharmacogenomics using DNA Microarray in the treatment of type 2 diabetes
| Project/Area Number |
24590693
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIKI Ikuyo 三重大学, 医学部, 講師 (20369614)
NOBORI Tsutomu 三重大学, 医学(系)研究科, 特任教授 (60106995)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | ファーマコゲノミクス / 2型糖尿病 / 薬剤トランスポーター / DNAマイクロアレイ / 糖尿病治療 |
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| Outline of Final Research Achievements |
Personalized medicine based on pharmacogenomics is being developed at the clinical stage. These developments in personalized medicine are strongly supported by marked innovations in genetic analyses. However, there are currently no potential companion diagnostics for common diseases. As common diseases are multifactorial, we appreciated that drugs pass through complex metabolic pathways was important rather than experience a single enzymatic modification to predict therapeutic efficacy.
We attempted DNA microarray system in type 2 diabetes mellitus (T2DM). Sitagliptin is most popular DPP4-i, but showed individual response variability. We designed a study to develop personalized medicine of T2DM by sitagliptin based on drug metabolism. Sitagliptin is excreted through kidney and pharmacokinetics is mostly regulated by P-glycoprotein (ABCB1) and organic anion transport (OAT3). We analyzed multiple genetic variants determined by the DMET including ABCB1 and OAT3 in T2DM patients.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Bilateral giant coronary aneurysms in a 40-year-old male with Noonan syndrome caused by a KRAS germline mutation.2014
Author(s)
Fujimoto N, Nakajima H, Sugiura E, Dohi K, Kanemitsu S, Yamada N, Aoki Y, Nakatani K, Shimpo H, Nobori T, Ito M
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Journal Title
Int J Cadiol
Volume: 173
Issue: 3
Pages: e63-e66
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immunological aspects in late phase of living donor liver transplant patients: usefulness of monitoring peripheral blood CD4+ adenosine triphosphate activity.2013
Author(s)
Mizuno S, Muraki Y, Nakatani K, Tanemura A, Kuriyama N, Ohsawa I, Azumi Y, Kishiwada M, Usui M, Sakurai H, Tabata M, Yamamoto N, Yamada T, Shiraki K, Takei Y, Nobori T, Okuda M, Isaji S.
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Journal Title
Clin Dev Immunol
Volume: -
Pages: 1-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Combination assays for evaluation of immune function and CYP3A5 genotype to identify the risk of infectious complications and mortality in living donor liver transplant patients.2013
Author(s)
Mizuno S, Nakatani K, Muraki Y, Tanemura A, Azumi Y, Kuriyama N, Ohsawa I, Kishiwada M, Usui M, Sakurai H, Tabata M, Okuda M, Nobori T, Isaji S.
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Journal Title
Ann Transplant
Volume: 18
Pages: 349-357
DOI
Related Report
Peer Reviewed
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[Journal Article] Kidney-protective effects of azelnidipine versus a diuretic in combination with olmesartan in hypertensive patients with diabetes and albuminuria: a randomized study.2013
Author(s)
Kojima M, Okubo S, Mizubayashi R, Isaka N, Machida H, Okamoto S, Hirota H, Takeuchi M, Kato T, Nakatani K, Mizuno O, Miyagawa K, Makino K, Okura T, Dohi Y, Ito M, Kimura G.
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Journal Title
Nephrol Dial Transplant
Volume: -
Issue: 7
Pages: 1802-1810
DOI
Related Report
Peer Reviewed
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[Journal Article] Relationship between CYP2C19 loss-of-function polymorphism and platelet reactivities with clopidogrel treatment in Japanese patients undergoing coronary stent implantation.2013
Author(s)
Nakata T, Miyahara M, Nakatani K, Wada H, Tanigawa T, Komada F, Hoshino K, Aoki T, Nishimura Y, Tamaru S, Ito M, Nishikawa M; McLordd Group.
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Journal Title
Circ J
Volume: 77
Pages: 1436-1444
NAID
Related Report
Peer Reviewed
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[Presentation] Pharmacogenomics using DNA microarray2014
Author(s)
Kaname Nakatani
Organizer
The 9th International Conference of Clinical Laboratory Automation and Robotics,
Place of Presentation
Yokohama Red Brik Warehouse
Year and Date
2014-04-18 – 2014-04-20
Related Report
Invited
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