| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
This study was proposed to examine the environmental factors affecting to the clinical laboratory tests using monozygotic twins, who have completely concordant genetic background. We indicated preliminaly that the methylation rates were different among the genotypes of polymorphisms in gene encoding the methylation-related enzymes, and that they can affect to the prognosis of autoimmune thyroid diseases. In addition, we have found 25-30 discordant twin pairs in the positivity of thyroid-specific autoantibodies, and are analyzing the intra-pair differences of methylation rates using these twins.
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