| Project/Area Number |
24590698
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kochi University |
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Principal Investigator |
SUGIURA Tetsuro 高知大学, 教育研究部医療学系, 教授 (50171145)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Hiroaki 高知大学, 教育研究部医療学系, 講師 (90346560)
TAKATA Jun 高知大学, 教育研究部医療学系, 教授 (90206748)
MORIMOTO Norihito 高知大学, 医学部附属病院, 副技師長 (60398055)
公文 義雄 高知大学, 医歯学系, 准教授 (40215033)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 急性冠症候群 / 血小板 / ヘリコバクター・ピロリ / 菌体膜成分 / 白血球 / 抗凝固剤 / 血小板凝集・活性化 / 菌体膜蛋白 |
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| Outline of Final Research Achievements |
We investigated to determine whether the infection by Helicobacter pylori possessing platelet-activating factor (lpp) influences the clinical pathology of acute coronary syndrome (ACS). Anti-lpp antibody was gained from a rabbit immunized with the lpp-His fusion protein made. In H. pylori infected Mongolian gerbil, the lpp was not found in blood. However, the 20-kDa was detected by western blotting with anti-lpp antibody in only sera from 2 H. pylori infected ACS patients. These indicated that the lpp transmigrates to blood vessels and might influence on the development of ACS.
Moreover, the lpp associated platelet-activating was synergistically enhanced with L-selectin. Our study showed the possibility that the lpp possesses anti-heparin effect and the affinity of lpp for calcium iron influence the platelet-activating.
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