The development of cancer related disease gene prediction system and the study of disease pathway.

• Project/Area Number: 24590704
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Keio University
• Principal Investigator: MITSUYAMA Susumu 慶應義塾大学, 医学部, 特任助教 (30296727)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 癌 / タンパク質 / 遺伝子 / 疾患 / 相互作用 / パスウェイ / データベース / 予測システム / 蛋白質

Outline of Final Research Achievements

This study collected the protein domains from SMART and NCBI Refseq for the cancer related gene/protein database “CancerProView “ (http://cancerproview.dmb.med.keio.ac.jp). Furthermore, this research developed another program to predict possible disease by comparing the protein domain with those of the unidentified diseases stored in CancerProView. These results would facilitate various cancer research, clinical diagnosis and treatment.

Research Products

• [Journal Article] CancerProView: a graphical image database of cancer-related genes and proteins. (2012)
  • Author(s): Susumu Mitsuyama, Nobuyoshi Shimizu
  • Journal Title: Genomics Volume: 100 Issue: 2 Pages: 81-92
  • DOI: 10.1016/j.ygeno.2012.05.011
  • Peer Reviewed
• [Presentation] がん関連タンパク質／遺伝子データベースCancerProView (2014)
  • Author(s): 満山 進, 清水信義
  • Organizer: 第37回日本分子生 物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-25
• [Presentation] CancerProView: がん関連疾患遺伝子／タンパク質相互作用データベース (2014)
  • Author(s): 満山 進, 清水信義
  • Organizer: 生命医薬情報学連合大会2014
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2014-10-02 – 2014-10-04
• [Presentation] CancerProViewのさらなる機能拡張 (2014)
  • Author(s): 満山 進, 清水信義
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25
• [Presentation] がん関連疾患遺伝子／タンパク質相互作用データベース CancerProView (2013)
  • Author(s): 満山 進, 清水信義
  • Organizer: 第 20回日本遺伝子診療学会大会
  • Place of Presentation: アクトシティ浜松コングレスセンター
• [Presentation] CancerProView: The cancer-related gene/protein interaction pathway image database system. (2013)
  • Author(s): Susumu Mitsuyama, Nobuyoshi Shimizu
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] New features of cancer-related protein / gene database "CancerProView" (2013)
  • Author(s): Susumu Mitsuyama, Nobuyoshi Shimizu
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Comparative analysis of the functional domains of various cancer-related proteins by CancerProView (2012)
  • Author(s): Susumu Mitsuyama, Nobuyoshi Shimizu
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
• [Remarks] CancerProView
  • URL: http://cancerproview.dmb.med.keio.ac.jp