Study of the fibrosis evaluation using the ultrasound in the chronic hepatitis.

• Project/Area Number: 24590711
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Fujita Health University
• Principal Investigator: OSAKABE Keisuke 藤田保健衛生大学, 医療科学部, 講師 (30290167)
• Co-Investigator(Kenkyū-buntansha): YOSHIOKA Kentaro 藤田保健衛生大学, 医学部, 教授 (60201852) ; HASHIMOTO Senjyu 藤田保健衛生大学, 医学部, 准教授 (60378049) ; NISHIKAWA Toru 藤田保健衛生大学, 医学研究科, 研究員 (20410714)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 線維化評価 / 慢性肝炎 / 肝硬変 / インターフェロン / 肝硬度測定 / 肝細胞癌

Outline of Final Research Achievements

The infection of hepatitis C virus (HCV) progresses to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Therefore we should diagnose the clinical stage exactly before starting treatment.We measured the liver stiffness (Vs) by the ultrasound and evaluated its correlation with the liver fibrosis stage and usefulness of the follow-up of Vs values during the Interferon (IFN) therapy.
The Vs values correlated with several blood fibrosis indexes (hyaluronic acid, APRI and FIB-4). Furthermore, the Vs values correlated with histological fibrosis stage (F0 - 4). A significant difference of Vs values was shown among the patients with different fibrosis stages. The cutoff of Vs values for each fibrosis stage was obtained. In the study of the follow-up of Vs values during the IFN therapy, the changes of Vs values reflected the different responses to the therapy. However, it seemed that the prediction of the response to IFN treatment by Vs values before treatment needs further studies.

Research Products

• [Journal Article] Measurement of liver stiffness as a non-invasive method for diagnosis of non-alcoholic fatty liver disease (2015)
  • Author(s): Kentaro Yoshioka
  • Journal Title: Hepatology Research Volume: 45 Issue: 2 Pages: 142-151
  • DOI: 10.1111/hepr.12388
• [Journal Article] Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C. (2014)
  • Author(s): Nishikawa T, Hashimoto S, Kawabe N, Harata M, Nitta Y, Murao M, Nakano T, Mizuno Y, Shimazaki H, Kan T, Nakaoka K, Takagawa Y, Ohki M, Ichino N, Osakabe K, Yoshioka K.
  • Journal Title: World Journal of Gastroenterology Volume: 7; 20(5) Issue: 5 Pages: 1289-1297
  • DOI: 10.3748/wjg.v20.i5.1289
  • Peer Reviewed
• [Presentation] B型慢性肝炎に対する抗ウイルス療法による肝硬度の変化と発癌との関係について (2014)
  • Author(s): 刑部恵介
  • Organizer: 第63回日本医学検査学会
  • Place of Presentation: 朱鷺メッセ・新潟県
  • Year and Date: 2014-05-17 – 2014-05-18
• [Presentation] B型慢性肝炎の肝硬度に及ぼす抗ウイルス療法の影響と肝発癌との関係についての検討 (2014)
  • Author(s): 刑部恵介
  • Organizer: 日本超音波医学会第87回学術大会
  • Place of Presentation: パシフィコ横浜・神奈川県
  • Year and Date: 2014-05-09 – 2014-05-11
• [Presentation] B型慢性肝炎の肝硬度に及ぼす抗ウイルス療法の影響と肝発癌との関係についての検討 (2014)
  • Author(s): 刑部恵介，市野直浩，西川 徹，加藤美穂，杉山博子，青山和佳奈，柴田亜委，川部直人，橋本千樹，吉岡健太郎
  • Organizer: 日本超音波医学会第87回学術集会
  • Place of Presentation: 横浜
• [Presentation] B型慢性肝炎に対する抗ウイルス療法による肝硬度の変化と発癌について (2014)
  • Author(s): 刑部恵介，市野直浩，西川 徹，杉本邦彦，加藤美穂，杉山博子，青山和佳奈，柴田亜委
  • Organizer: 第63回日本医学検査学会
  • Place of Presentation: 新潟
• [Presentation] C型慢性肝炎に対するインターフェロン治療による肝硬度の変化についての検討 (2013)
  • Author(s): 刑部恵介，市野直浩，西川 徹，杉山博子，加藤美穂，青山和佳奈，鈴木亜委，岸 詩織，原田雅生，川部直人，橋本千樹，吉岡健太郎
  • Organizer: 日本超音波医学会第86回学術集会
  • Place of Presentation: 大阪
• [Presentation] HCV感染症におけるVTTQ による肝線維化評価 (2012)
  • Author(s): 西川 徹，吉岡健太郎，橋本千樹，川部直人，原田雅生，市野直浩，刑部恵介，加藤美穂，杉山博子，青山和佳奈
  • Organizer: 日本超音波医学会第85回学術集会
  • Place of Presentation: 東京