| Project/Area Number |
24590711
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
OSAKABE Keisuke 藤田保健衛生大学, 医療科学部, 講師 (30290167)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIOKA Kentaro 藤田保健衛生大学, 医学部, 教授 (60201852)
HASHIMOTO Senjyu 藤田保健衛生大学, 医学部, 准教授 (60378049)
NISHIKAWA Toru 藤田保健衛生大学, 医学研究科, 研究員 (20410714)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 線維化評価 / 慢性肝炎 / 肝硬変 / インターフェロン / 肝硬度測定 / 肝細胞癌 |
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| Outline of Final Research Achievements |
The infection of hepatitis C virus (HCV) progresses to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Therefore we should diagnose the clinical stage exactly before starting treatment.We measured the liver stiffness (Vs) by the ultrasound and evaluated its correlation with the liver fibrosis stage and usefulness of the follow-up of Vs values during the Interferon (IFN) therapy.
The Vs values correlated with several blood fibrosis indexes (hyaluronic acid, APRI and FIB-4). Furthermore, the Vs values correlated with histological fibrosis stage (F0 - 4). A significant difference of Vs values was shown among the patients with different fibrosis stages. The cutoff of Vs values for each fibrosis stage was obtained. In the study of the follow-up of Vs values during the IFN therapy, the changes of Vs values reflected the different responses to the therapy. However, it seemed that the prediction of the response to IFN treatment by Vs values before treatment needs further studies.
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