|Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|Outline of Final Research Achievements
This paper showed that the infiltration of inflammatory cells such as macrophages and lymphocytes into synovitis lesions and the expression of TGF-β, VEGF, MMP-3 and -9 in arthritis-model mice are elevated in comparison to control mice. Proteomics-based quantitative analysis showed the elevated expression of α-enolase and other unidentified markers in synovial tissues of arthritis. Tissue sections for imaging mass spectrometry could not obtained by microtome because of bone tissues and small samples.