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Development of homogenous and quantitative immunoassay system with magnetic detection

Research Project

Project/Area Number 24590716
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionNagasaki International University

Principal Investigator

KUMA Hiroyuki  長崎国際大学, 薬学部, 准教授 (40435136)

Co-Investigator(Kenkyū-buntansha) HAMASAKI Naotaka  長崎国際大学, 薬学部, 客員教授 (00091265)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords磁気的免疫検査システム / ホモジニアスアッセイ / 磁気マーカー / SQUID / 抗原抗体反応 / 医療・福祉 / 磁気検出 / ホモジニアス / 免疫検査
Outline of Final Research Achievements

In this study, we have developed the homogenous and quantitative immunoassay system with magnetic marker, polystyrene beads and SQUID sensor.
We also demonstrated the ability for magnetic markers to measure various biological targets (proteins, fugus, cedar pollen) without BF separation. This system has potential for use not only in clinical and laboratory immunoassays but also for medical inspections, identification of environmental pollution factors, and configuration of food examination tests.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (4 results) (of which Invited: 2 results) Remarks (2 results)

  • [Journal Article] 国際的な標準化活動とJSCC2014

    • Author(s)
      濱崎 直孝
    • Journal Title

      臨床検査

      Volume: 58 Pages: 150-155

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 磁気検出法を用いた高速・高感度な免疫検査システム2014

    • Author(s)
      隈 博幸
    • Journal Title

      生物化学的測定研究会年報

      Volume: 18 Pages: 25-36

    • Related Report
      2013 Research-status Report
  • [Journal Article] Activated protein C anticoagulant system dysfunction and thrombophilia in Asia2013

    • Author(s)
      Hamasaki N, Kuma H, Tsuda H.
    • Journal Title

      Ann. Lab. Med.

      Volume: 33 Issue: 1 Pages: 8-13

    • DOI

      10.3343/alm.2013.33.1.8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Beneficial effect of EPA (20:5 n-3 PUFA) on preventing venous thromboembolism: a rat tail thrombosis model experiment.2013

    • Author(s)
      Kuma H, Nagashima R, Hatae H, Tsuda T, Hamasaki N
    • Journal Title

      Thromb Res

      Volume: 131(1) Issue: 1 Pages: 107-108

    • DOI

      10.1016/j.thromres.2012.09.014

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of magnetic markers for liquid-phase immunoassays using Brownian relaxation2012

    • Author(s)
      K.Enpuku, et al
    • Journal Title

      Jpn.J.Appl.Phys.

      Volume: 51 Issue: 2R Pages: 23002-23002

    • DOI

      10.1143/jjap.51.023002

    • NAID

      40019170631

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] APC凝固制御異常と血栓性素因2014

    • Author(s)
      濱崎 直孝
    • Organizer
      第36回日本血栓止血学会プロテインS研究会シンポジウム
    • Place of Presentation
      大阪国際交流センター
    • Year and Date
      2014-05-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Homogenous quantitative analysis of human parathyroid hormone by use of magnetic markers and2013

    • Author(s)
      Maeda C, Hisamatsu K, Mitsuse, K, Egashira, S,
    • Organizer
      IFCC EuroMedlab 2013
    • Place of Presentation
      イタリア・ミラノ
    • Related Report
      2013 Research-status Report
  • [Presentation] Homogenous quantitative analysis of human parathyroid hormone by use of magnetic markers and SQUID magnetometer2013

    • Author(s)
      Maeda C, Hisamatsu K, Mitsuse, K, Egashira, S, Hamasaki, N, Enpuku, K, Kuma, H
    • Organizer
      International Federation of Clinical Chemistry
    • Place of Presentation
      イタリア・ミラノ
    • Related Report
      2012 Research-status Report
  • [Presentation] 磁気検出法を用いた高速・高感度な免疫検査システム

    • Author(s)
      隈 博幸
    • Organizer
      第18回生物化学的測定研究会学術集会
    • Place of Presentation
      キャンパスプラザ京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 長崎国際大学薬学部臨床検査学研究室HP(磁気検出法を用いた新規免疫検査システムの開発)

    • URL

      http://www.niu.ac.jp/~pharm1/lab/cclm/immunoassay.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 長崎国際大学薬学部臨床検査学研究室ホームページ

    • URL

      http://www.niu.ac.jp/~pharm1/lab/cclm/immunoassay.html

    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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