Evaluation of new radical measurement method using imuno-spin trapping with anti-spin trap antibody
| Project/Area Number |
24590718
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
SATO Keizo 九州保健福祉大学, 薬学部, 教授 (00315293)
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| Co-Investigator(Kenkyū-buntansha) |
SHINYA Tomohiro 九州保健福祉大学, 薬学部薬学科, 助教 (60551299)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 酸化ストレス / フリーラジカル / ラジカル捕捉剤 / 抗ラジカル捕捉剤抗体 / 電子スピン共鳴 |
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| Outline of Final Research Achievements |
Oxidative Stress have important roles in various diseases such as diabetes, infectious disease, inflammatory disease, lung injury and aging. Threrfore, development of a correct and handy method of oxidative stress is desired. So we have developed the new radical measurement method which is stable and high sensitive by using an antibody of a radical trap agent. As a results, It could be confirmed that it can be gauged, a immunostain method, ELISA method and HPLC method. Consequently, I could think this method could contribute to a study of all fields as new oxidation stress measurement.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.2013
Author(s)
Tanaka K, Ishihara T, Sugizaki T, Kobayashi D, Yamashita Y, Tahara K, YamakawaN, Iijima K, Mogushi K, Tanaka H, Sato K, Suzuki H, Mizushima T.
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Journal Title
Nature Commun.
Volume: 4
Pages: 2686-2686
Related Report
Peer Reviewed
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[Presentation] 感染症と酸化ストレス2014
Author(s)
佐藤圭創
Organizer
第９回新宿呼吸器感染症フォーラム
Place of Presentation
慶応大学（東京都港区）
Year and Date
2014-11-18
Related Report
Invited
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