The roles of glycoprotein non-metastatic melanoma B (Gpnmb) in the modulation of ion channel activities and pain conduction

Research Project

Project/Area Number	24590724
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Pain science
Research Institution	Kanazawa University
Principal Investigator	SHIGERU Yokoyama 金沢大学, 子どものこころの発達研究センター, 特任教授 (00210633)
Co-Investigator(Kenkyū-buntansha)	YOSHIKAWA Hiroaki 金沢大学, 保健管理センター, 教授 (10272981)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	痛み / 神経損傷 / Gpnmb
Outline of Final Research Achievements	The expression of glycoprotein non-metastatic melanoma B (Gpnmb) was up-regulated in both sciatic nerve and spinal cord injuries. In the lesioned sites, Gpnmb-immunoreactive cells were co-stained with markers including OX-42, ED1, and OX6. These results suggest that Gpnmb, which is produced by macrophages and microglia, may play important roles in pathophysiological processes in both peripheral and central nerve injuries.

Report

(4 results)