| Project/Area Number |
24590725
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Chubu University (2014)
Nagoya University (2012-2013) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAGUCHI Toru 名古屋大学, 環境医学研究所, 助教 (90464156)
KATANOSAKA Yuki 岡山大学, 大学院医歯薬学総合研究科, 助教 (60432639)
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| Research Collaborator |
NARUSE Keiji 岡山大学, 大学院医歯薬学総合研究科, 教授
TAKATSU Satomi 岡山大学, 大学院医歯薬学総合研究科, 博士研究員
MIZUMURA Kazue 中部大学, 生命健康科学部, 教授
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | TRPV2 / 疼痛 / 機械受容 / 侵害受容器 / 一次知覚神経 / 脊髄神経節 / 痛覚 / 熱痛覚 |
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| Outline of Final Research Achievements |
In this research, we explored an unknown function of TRPV2, a nonselective cation channel, in adult primary sensory neurons by construction and analysis of a primary sensory neuron-specific conditional knock-out mice of TRPV2 (cKO). There was no apparent difference in number, population, and morphology of the primary sensory neurons, and their axonal development between the cKO mice and normal littermates. However, the nocifensive behavior of the mice against noxious mechanical stimuli and the incidence of stretch-sensitive primary sensory neurons with relatively high-thresholds were significantly reduced in cKO mice compared to the normal mice. These results suggest that TRPV2 in the adult primary sensory neurons is involved in the mechanical nociception.
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