| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Sex differences in pain perception is well known in animals and men. One of the mechanisms of these differences is presumed to be a plasticity of descending inhibition. We investigated changes of pain threshold and activities of anterior cingulate cortex (ACCX) after stress loading or acupuncture for activation of descending inhibition.The main results are as follows:1)Neuronal activities of ACCX were changed during menstrual cycle in female,however, no sequential changes were observed in male rats.2)There were no chronological changes of antinociceptive effects evoked by acupuncture in both sex.These results suggest that sex differences in pain "sensation" is not clear, but, those in emotional pain "perception" were strongly observed. Plasticity of descending inhibition is thought to be involved in these sex differences.
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