Effect of pulsed radiofrequency current on expression of substance P,CGRP,and BDNF in the DRG neurons of neuropathic pain model rats induced by resiniferatoxin
| Project/Area Number |
24590728
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOSHIDA Tomohiro 宮崎大学, 医学部, 助教 (20441842)
YONAHA Tetsu 宮崎大学, 医学部, 助教 (70468023)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | パルス高周波法 / パルス高周波 / pulsed radiofrequency / 神経障害痛 / 間欠的高周波照射 |
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| Outline of Final Research Achievements |
We examined the Pulsed Radiofrequency (PRF) mechanism by evaluating the protein expression level in the dorsal root ganglion (DRG) of neuropathic pain model rats induced by resiniferatoxin.
we demonstrated that expression levels of Substance P, calcitonin gene-related peptide, and the brain-derived neurotrophic factor in the DRG neurons were decreased by RTX, and that PRF current restored these proteins’ expression levels. We propose that one of mechanisms of PRF current to neuropathic pain may be the modulatory effect of neurotransmitter and neurotrophic factor expression in the DRG neurons.
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Report
(4 results)
Research Products
(2 results)
