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Effect of pulsed radiofrequency current on expression of substance P,CGRP,and BDNF in the DRG neurons of neuropathic pain model rats induced by resiniferatoxin

Research Project

Project/Area Number 24590728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionUniversity of Miyazaki

Principal Investigator

TANAKA nobuhiko  宮崎大学, 医学部, 講師 (30264394)

Co-Investigator(Kenkyū-buntansha) KOSHIDA Tomohiro  宮崎大学, 医学部, 助教 (20441842)
YONAHA Tetsu  宮崎大学, 医学部, 助教 (70468023)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsパルス高周波法 / パルス高周波 / pulsed radiofrequency / 神経障害痛 / 間欠的高周波照射
Outline of Final Research Achievements

We examined the Pulsed Radiofrequency (PRF) mechanism by evaluating the protein expression level in the dorsal root ganglion (DRG) of neuropathic pain model rats induced by resiniferatoxin.
we demonstrated that expression levels of Substance P, calcitonin gene-related peptide, and the brain-derived neurotrophic factor in the DRG neurons were decreased by RTX, and that PRF current restored these proteins’ expression levels. We propose that one of mechanisms of PRF current to neuropathic pain may be the modulatory effect of neurotransmitter and neurotrophic factor expression in the DRG neurons.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Presentation (2 results)

  • [Presentation] 神経障害痛に対する間欠的高周波照射の作用メカニズムの検討ーDRGニューロンでのCGRP、BDNFの発現への影響ー2015

    • Author(s)
      越田智広, 田中信彦, 他
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-05-28 – 2015-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of Pulsed Radiofrequency Current on Expression of Substance P, CGRP and BDNF In the DRG Neurons of Neuropathic Pain Model Rats Induced by Resiniferatoxin2014

    • Author(s)
      T.Koshida, N.Tanaka, et al
    • Organizer
      ASRA 13th Annual Pain Medicine Meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2014-11-13 – 2014-11-16
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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