| Project/Area Number |
24590730
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIGUCHI Norikazu 和歌山県立医科大学, 医学部, 講師 (90433341)
KOBAYASHI Yuka 和歌山県立医科大学, 医学部, 助教 (20511562)
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| Research Collaborator |
KADOWAKI Yui
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 慢性疼痛 / 神経障害性疼痛 / 血管新生 / VEGF / サイトカイン / 炎症 / 血管内皮細胞 / ネットワーク / マクロファージ / 神経炎症 / 坐骨神経 / ケモカイン / エピジェネティクス / CXCR4 |
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| Outline of Final Research Achievements |
In this study, we determined the molecular mechanism of chronic pain through relationship between neuron and angiogenesis. Macrophages and neutrophils were accumulated into peripheral nerves after injury, and they produced vascular endothelial growth factor (VEGF). We identified the progression of pathological angiogenesis in the injured nerves using immunohistochemistry, and these phenomenon was confirmed by proliferation of endothelial cells by VEGF signaling. Moreover, pharmacological inhibition of VEGF signaling was able to prevent injury-induced chronic pain. In conclusion, we propose that VEGF signaling-dependent pathological angiogenesis in the injured peripheral nerves might be key component of chronic pain.
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