Mechanism analysis of the trigeminal nervous system modification on cortical spreading depression.
| Project/Area Number |
24590732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Keio University |
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Principal Investigator |
TORIUMI Haruki 慶應義塾大学, 医学部, 講師(非常勤) (30528203)
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| Co-Investigator(Kenkyū-buntansha) |
UNEKAWA Miyuki 慶應義塾大学, 医学部, 助教 (10548481)
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| Research Collaborator |
EBINE Taeko 慶應義塾大学, 医学研究科
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 脳循環代謝 / CSD / 片頭痛 / 脳血管障害 / ｔrigger point / 鍼灸 / acupuncture / 統合医療 / 大脳皮質皮質拡延性抑制 / 三叉神経 / 疼痛制御 / Acupuncture / 鍼灸の科学化 / 大脳皮質拡延性抑制 / PID / 頭痛 / Moxibustion |
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| Outline of Final Research Achievements |
We studied about the factor which has an influence on an occurrence threshold of Cortical Spreading Depression (CSD), and got many outcomes. The most important outcome is that a trigger point on the trigeminal nervous territory made decrease of the CSD threshold, like a direct stimulus of the pain receptors. Our results suggest the trigger point has a potential to be an intervention pathway for these disorders. These outcomes contribute to building of the new treatment strategy for migraine, headache and the cerebrovascular accident.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] 34. Microvascular sprouting, extension, and creation of new capillary connection with adaptation of the neighboring astrocytes in adult mouse cortex under chronic hypoxia2014
Author(s)
Masamoto K, Takuwa H, Seki C, Taniguchi J, Itoh Y, Tomita Y, Toriumi H, Unekawa M, Kawaguchi H, Ito H, Suzuki N, Kanno I
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Journal Title
J Cereb Blood Flow Metab
Volume: 34
Issue: 2
Pages: 325-31
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Differential cellular localization of antioxidant enzymes in the trigeminal ganglion.2013
Author(s)
Sato H, Shibata M, Shimizu T, Shibata S, Haruki T, Ebine T, Kuroi T, Iwashita T, Funakubo M, Kayama Y, Akazawa C, Wajima K, Nakagawa T. Okano H. Suzuki N
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Journal Title
Neuroscience
Volume: 248
Pages: 345-358
DOI
Related Report
Peer Reviewed
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[Presentation] Repeated 3D liv e imaging of microvascular-astroglia restructuring induced by hypoxia in mouse cerebral cortex.2013
Author(s)
Masamoto K, Takuwa H, Sugashi T, Yamada Y, Tomita Y, Unekawa M, Toriumi H, Itoh Y, Suzuki N, Ito H, Kanno I.
Organizer
第38回日本微小循環学会総会
Place of Presentation
東京
Related Report
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