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Mechanism analysis of the trigeminal nervous system modification on cortical spreading depression.

Research Project

Project/Area Number 24590732
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionKeio University

Principal Investigator

TORIUMI Haruki  慶應義塾大学, 医学部, 講師(非常勤) (30528203)

Co-Investigator(Kenkyū-buntansha) UNEKAWA Miyuki  慶應義塾大学, 医学部, 助教 (10548481)
Research Collaborator EBINE Taeko  慶應義塾大学, 医学研究科
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords脳循環代謝 / CSD / 片頭痛 / 脳血管障害 / trigger point / 鍼灸 / acupuncture / 統合医療 / 大脳皮質皮質拡延性抑制 / 三叉神経 / 疼痛制御 / Acupuncture / 鍼灸の科学化 / 大脳皮質拡延性抑制 / PID / 頭痛 / Moxibustion
Outline of Final Research Achievements

We studied about the factor which has an influence on an occurrence threshold of Cortical Spreading Depression (CSD), and got many outcomes. The most important outcome is that a trigger point on the trigeminal nervous territory made decrease of the CSD threshold, like a direct stimulus of the pain receptors. Our results suggest the trigger point has a potential to be an intervention pathway for these disorders. These outcomes contribute to building of the new treatment strategy for migraine, headache and the cerebrovascular accident.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (26 results)

All 2015 2014 2013 2012

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 1 results) Presentation (14 results) (of which Invited: 6 results) Book (1 results)

  • [Journal Article] 34. Microvascular sprouting, extension, and creation of new capillary connection with adaptation of the neighboring astrocytes in adult mouse cortex under chronic hypoxia2014

    • Author(s)
      Masamoto K, Takuwa H, Seki C, Taniguchi J, Itoh Y, Tomita Y, Toriumi H, Unekawa M, Kawaguchi H, Ito H, Suzuki N, Kanno I
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 34 Issue: 2 Pages: 325-31

    • DOI

      10.1038/jcbfm.2013.201

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 頭痛専門診療における鍼灸併用の可能性2013

    • Author(s)
      鳥海春樹
    • Journal Title

      神経内科

      Volume: 78 Pages: 550-555

    • NAID

      130004505140

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of extracellular signal-regulated kinase in the trigeminal ganglion following both treatment of the dura mater with capsaicin and cortical spreading depression.2013

    • Author(s)
      Iwashita T, Shimizu T, Shibata M, Toriumi H, Ebine T, Funakubo M, Suzuki N.
    • Journal Title

      Neurosci Res.

      Volume: 77 Issue: 1-2 Pages: 110-9

    • DOI

      10.1016/j.neures.2013.08.001

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential cellular localization of antioxidant enzymes in the trigeminal ganglion.2013

    • Author(s)
      Sato H, Shibata M, Shimizu T, Shibata S, Haruki T, Ebine T, Kuroi T, Iwashita T, Funakubo M, Kayama Y, Akazawa C, Wajima K, Nakagawa T. Okano H. Suzuki N
    • Journal Title

      Neuroscience

      Volume: 248 Pages: 345-358

    • DOI

      10.1016/j.neuroscience.2013.06.010

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] “Potassium-induced cortical spreading depression bilaterally suppresses the electroencephalogram but only ipsilaterally affects red blood cell velocity in intraparenchymal capillaries.”2013

    • Author(s)
      Unekawa M, Tomita Y, Toriumi H, Masamoto K, Kanno I, Suzuki N.
    • Journal Title

      J Neurosci Res.

      Volume: 91 Issue: 4 Pages: 578-584

    • DOI

      10.1002/jnr.23184

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] TRPV1受容体を介した三叉神経の侵害刺激がCSD発生に及ぼす影響2013

    • Author(s)
      鳥海春樹, 畝川美悠紀, 黒井俊哉, 柴田護, 清水利彦, 鈴木則宏.
    • Journal Title

      日本頭痛学会誌

      Volume: 39 Pages: 303-5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acupuncture; as a valuable tool for headache.2012

    • Author(s)
      Toriumi H, Ebine T, Kuroi T, Mamoru S, ShimizuT, Suzuki N.
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 52 Pages: 1297-8

    • NAID

      130004505140

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reduction of TRPV1 expression in the trigeminal system by botulinum neurotoxin type-A.2012

    • Author(s)
      Shimizu T
    • Journal Title

      Neurobiol Dis

      Volume: 48 Issue: 3 Pages: 367-378

    • DOI

      10.1016/j.nbd.2012.07.010

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppressive effect of chronic peroral topiramate on potassium-induced cortical spreading depression in rats2012

    • Author(s)
      Unekawa M, Tomita Y, Toriumi H, Suzuki N
    • Journal Title

      Cephalalgia

      Volume: 32 Issue: 7 Pages: 518-527

    • DOI

      10.1177/0333102412444015

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alterations in microglia and astrocytes in the trigeminal nucleus caudalis by repetitive TRPV1 stimulation on the trigeminal nociceptors.2012

    • Author(s)
      Kuroi T, Shimizu T, Shibata M, Toriumi H, Funakubo M, Iwashita T, Sato H, Koizumi K, Suzuki N.
    • Journal Title

      Neuroreport.

      Volume: 23 Issue: 9 Pages: 560-5

    • DOI

      10.1097/wnr.0b013e3283546242

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sustained decrease and remarkable increase in red blood cell velocity in intraparenchymal capillaries associated with potassium-induced cortical spreading depression2012

    • Author(s)
      Unekawa M, Tomita M, Tomita Y, Toriumi H, Suzuki N
    • Journal Title

      Microcirculation

      Volume: 19 Issue: 2 Pages: 166-74

    • DOI

      10.1111/j.1549-8719.2011.00143.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] シンポジウム2 神経内科領域の鍼灸治療:一次性頭痛の病態と鍼治療の可能性2015

    • Author(s)
      鳥海 春樹
    • Organizer
      第68回日本自律神経学会総会
    • Place of Presentation
      大宮市、埼玉県、ラフレ埼玉
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] シンポジウムⅣ 頭痛:病態を鍼灸から考察する2014

    • Author(s)
      鳥海 春樹
    • Organizer
      日本早期認知症学会第15回学術大会 in 佐倉
    • Place of Presentation
      佐倉市、千葉県、佐倉市ユーカリが丘ウィシュトンホテル
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] シンポジウム「頭痛の玉手箱」神経内科鍼外来の頭痛~経験則の科学化と適正活用による治療戦略の多様化を模索する~2013

    • Author(s)
      鳥海春樹
    • Organizer
      第41回日本頭痛学会総会
    • Place of Presentation
      いわて県民情報交流センター
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] シンポジウム「ここまでわかった鍼灸医学・基礎と臨床の交流」2013

    • Author(s)
      鳥海春樹
    • Organizer
      第62回全日本鍼灸学会学術大会
    • Place of Presentation
      アクロス福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 特別講演「鍼灸医療から見た代替医療の可能性」2013

    • Author(s)
      鳥海春樹
    • Organizer
      第9回統合医療展
    • Place of Presentation
      東京ビックサイト
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Irbetanの長期投与が一過性局所脳血管閉塞領域の血管への細胞接着に及ぼす効果2013

    • Author(s)
      鳥海春樹, 海老根妙子, 萱間洋平, 畝川美悠紀, 山田哲, 冨田裕, 伊藤義彰, 鈴木則宏.
    • Organizer
      第38回日本脳卒中学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Repeated 3D liv e imaging of microvascular-astroglia restructuring induced by hypoxia in mouse cerebral cortex.2013

    • Author(s)
      Masamoto K, Takuwa H, Sugashi T, Yamada Y, Tomita Y, Unekawa M, Toriumi H, Itoh Y, Suzuki N, Ito H, Kanno I.
    • Organizer
      第38回日本微小循環学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Propagation of changes in diameter of pial a rteries and cerebral blood flow following cortical spreading depression in anesthetized mice.2013

    • Author(s)
      Unekawa M, Tomita Y, Toriumi H, Osada T, Masamoto K, Itoh Y, Kanno I, Suzuki N.
    • Organizer
      第38回日本微小循環学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] シンポジウム「神経内科診療における鍼灸活用の可能性を探る」 頭痛専門診療における鍼灸併用の可能性2012

    • Author(s)
      鳥海春樹
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 頭痛外来における鍼治療の併用と効果検討2012

    • Author(s)
      鳥海春樹, 海老根妙子, 萱間洋平, 柴田護, 清水利彦, 鈴木則宏.
    • Organizer
      第40回日本頭痛学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Alterlation in the threshold of potassiumu concentration for evoking cortical spreading depression during the natural estrous cycle in mice2012

    • Author(s)
      T. Ebine, H. Toriumi, T. Iwashita, M. Shibata, T. Shimizu, N. Suzuki.
    • Organizer
      The 4th Asian Regional Conference for Headache
    • Place of Presentation
      台北
    • Related Report
      2012 Research-status Report
  • [Presentation] 齧歯類脳幹および三叉神経節におけるTRPM8の局在―免疫組織化学染色による検討―2012

    • Author(s)
      萱間洋平,鳥海春樹, 海老根妙子, 柴田護, 清水利彦, 鈴木則宏.
    • Organizer
      第40回日本頭痛学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 麻酔下マウスにおける大脳皮質性拡延性 抑制誘発時の脳表動静脈および毛細血管の口径と脳血流の変化2012

    • Author(s)
      畝川美悠紀, 冨田裕, 鳥海春樹, 長田高志, 正本和人, 川口拓之, 伊藤義彰, 菅野巖, 鈴木則宏.
    • Organizer
      第24回日本脳循環代謝学会総会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Presentation] マウス大脳皮質虚血辺縁部に おけるNeuro-glio-vascular unitのin vivo形態解析.2012

    • Author(s)
      正本和人, 冨田裕, 鳥海春樹, 青木伊知男, 畝川美悠紀, 田桑弘之, 伊藤浩, 伊藤義彰, 鈴木則宏, 菅野巖.
    • Organizer
      第24回日本脳循環代謝学会総会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report
  • [Book] Annual Review 神経2013  -神経疾患に対する鍼灸 Acupuncture 活用の現状-2013

    • Author(s)
      鳥海春樹
    • Total Pages
      380
    • Publisher
      (株)中外医学社
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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