Study on novel mechanism for TRPV1-mediated control of neuropathic pain
| Project/Area Number |
24590734
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経障害性疼痛 / 骨髄移植 / 骨髄キメラマウス / カプサイシン / TRPV1 / ノックアウトマウス / 触アロディニア |
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| Outline of Final Research Achievements |
We studied mechanisms for TRPV1-mediated control of neuropathic pain in mice. We found recruitment of immune cells and differentiation and hypertrophy of adipocyte in the injured sciatic nerve tissue. Stimulation of TRPV1 on immune cells inhibited the development of neuropathic pain. Interaction of immune cells and adipocytes in the injured nerve tissue facilitates the development of neuropathic pain, revealed by gene expression profiling in co-culture of immune cells and adipocytes. These studies suggest that TRPV1 on immune cells is a target molecule for the control of neuropathic pain.
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Report
(4 results)
Research Products
(8 results)
