| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We investigated the molecular mechanisms of mechanical allodynia using the rat L5 spinal nerve ligation model. Following peripheral nerve damage, the injured heavily myelinated primary afferent neurons up-regulated BDNF and NPY expression. Our data suggested that these neuropeptides were released in the ipsilateral gracile nucleus by spontaneous firing of these neurons and facilitated touch sense processing causing mechanical allodynia. Additionally, we found that muscle-innervating primary afferent neurons normally lacked Nav1.7, an alpha-subunit of voltage-gated sodium channel, but began to express this channel following nerve injury. Nav1.7 may exert an important role for spontaneous firing.
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