Development of bioinformatics tool to predict the hepatotoxicity of chemicals
| Project/Area Number |
24590743
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | University of Toyama |
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Principal Investigator |
INADERA Hidekuni 富山大学, 大学院医学薬学研究部(医学), 教授 (10301144)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 化学物質 / 毒性学 / インフォマティクス / トランスクリプトーム |
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| Outline of Final Research Achievements |
The development of systems for analyzing global expression patterns by molecular profiling techniques provides opportunities to establish the basis of toxicological responses. The general profile of gene expression provides insights into the molecular mechanisms by which chemicals might exert toxic effects. We developed a customized DNA microarray system and analyzed gene expression changes in response to representative chemicals. In vitro hepatotoxicity prediction systems using primary cultured hepatocytes have been used in this study. We found in vitro toxicity systems cannot fully reflect the in vivo expression profile and cellular function. We tried to establish the bioinformatics tool which can predict the in vivo response by using the transcriptome data of in vitro systems.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Birth cohort study on the effects of desert dust exposure on children’s health: protocol of an adjunct study of the Japan Environment and Children’s Study.2014
Author(s)
Kanatani KT, Adachi Y, Sugimoto N, Noma H, Onishi K, Hamazaki K, Takahashi Y, Ito I, Egawa M, Sato K, Go T, Kurozawa Y, Inadera H, Konishi I, Nakayama T, and Japan Environment and Children`s Study Group.
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Journal Title
BMJ Open
Volume: 4
Issue: 6
Pages: e004863-e004863
DOI
Related Report
Peer Reviewed / Open Access
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