| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Outline of Final Research Achievements |
We investigated whether variants in GCK, G6PC2, and MTNR1B interact with the effect of dietary carbohydrate quality on glucose homeostasis. The subjects were fifth and eighth graders. Plasma glucose and serum insulin levels were measured. Dietary intake was assessed using a brief self-administered diet history questionnaire, and anthropometric data were obtained. GCK and G6PC2 variants were significantly associated with fasting glucose levels and β-cell function. In low-dietary-fiber and high-glycemic-index groups, the effect sizes of the GCK and G6PC2 variants on fasting glucose levels were increased. A MTNR1B variant was associated with fasting insulin levels, insulin sensitivity, and β-cell function in boys. These associations were apparent in low-dietary-fiber group. Carbohydrate quality modified the association of variants in these genes with glucose homeostasis. The interaction between genetic factors and dietary quality on fasting glucose levels should be considered.
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