glucose metabolism

• Project/Area Number: 24590748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Yamaguchi University
• Principal Investigator: OKUDA Masayuki 山口大学, 理工学研究科, 教授 (50274171)
• Co-Investigator(Kenkyū-buntansha): OKAYAMA Naoko 山口大学, 医学部附属病院・副臨床, 衛生検査技師長 (40420541)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 糖代謝 / 小児 / 遺伝子多型 / 食習慣

Outline of Final Research Achievements

We investigated whether variants in GCK, G6PC2, and MTNR1B interact with the effect of dietary carbohydrate quality on glucose homeostasis. The subjects were fifth and eighth graders. Plasma glucose and serum insulin levels were measured. Dietary intake was assessed using a brief self-administered diet history questionnaire, and anthropometric data were obtained. GCK and G6PC2 variants were significantly associated with fasting glucose levels and β-cell function. In low-dietary-fiber and high-glycemic-index groups, the effect sizes of the GCK and G6PC2 variants on fasting glucose levels were increased. A MTNR1B variant was associated with fasting insulin levels, insulin sensitivity, and β-cell function in boys. These associations were apparent in low-dietary-fiber group. Carbohydrate quality modified the association of variants in these genes with glucose homeostasis. The interaction between genetic factors and dietary quality on fasting glucose levels should be considered.

Research Products

• [Journal Article] Dietary intake, FTO genetic variants and adiposity: a combined analysis of over 16,000 children and adolescents (2015)
  • Author(s): Qi, Q., M. K. Downer, T. O. Kilpelainen, H. R. Taal, S. J. Barton, I. Ntalla, M. Standl, V. Boraska, V. Huikari, J. C. Kiefte-de Jong, A. Korner, T. A. Lakka, G. Liu, J. Magnusson, M. Okuda, et al.
  • Journal Title: Diabetes Volume: - Issue: 7 Pages: 2467-2476
  • DOI: 10.2337/db14-1629
  • NAID: 40020912768
  • Peer Reviewed
• [Journal Article] Acute pericardial effusion representing the TNF-α-mediated severe inflammation but not the coronary artery outcome of Kawasaki disease (2014)
  • Author(s): Okada, S., S. Hasegawa, Y. Suzuki, T. Matsubara, M. Shimomura, M. Okuda, T. Ichiyama and S. Ohga
  • Journal Title: Scandinavian Journal of Rheumatology Volume: 29 Issue: 3 Pages: 1-6
  • DOI: 10.3109/03009742.2014.956140
  • Peer Reviewed
• [Journal Article] Fat-mass and obesity-associated gene variant and changes of body mass index from ages 3 to 13 years. (2013)
  • Author(s): Shinozaki K, Okuda M, Hinoda Y, Okayama N, Fukuda T, Kunitsugu I.
  • Journal Title: Obesity Reseach and Clinical Practice Volume: online Issue: 4 Pages: e382-e387
  • DOI: 10.1016/j.orcp.2013.07.005
  • Peer Reviewed
• [Journal Article] Psychosocial functioning and self-rated health in Japanese school-aged children: a cross-sectional study. (2013)
  • Author(s): Okuda M, Sekiya M, Okuda Y, Kunitsugu I, Yoshitake N.
  • Journal Title: Nursing and Health Sciences Volume: 15 Issue: 2 Pages: 157-163
  • DOI: 10.1111/nhs.12005
  • Peer Reviewed
• [Journal Article] Validity of self-reported body mass index of Japanese children and adolescents (2012)
  • Author(s): Yoshitake N, Okuda M, Sasaki S, Kunitsugu I, Hobara T.
  • Journal Title: Pediatrics International Volume: 54 Issue: 3 Pages: 397-401
  • DOI: 10.1111/j.1442-200x.2011.03541.x
  • Peer Reviewed
• [Journal Article] Meat intake frequency and anemia in Japanese children and adolescents (2012)
  • Author(s): Kunitsugu I, Okuda M, Sugiyama S, Yoshitake N, Tanizawa Y, Sasaki S Hobara T.
  • Journal Title: Nursing and Health Sciences. Volume: 14 Issue: 2 Pages: 197-203
  • DOI: 10.1111/j.1442-2018.2012.00678.x
  • Peer Reviewed
• [Journal Article] Breakfast habits among adolescents and their association with daily energy and fish, vegetable, and fruit intake: a community-based cross-sectional study (2012)
  • Author(s): Sugiyama S, Okuda M, Sasaki S, Kunitsugu I, Hobara T.
  • Journal Title: Env Health Prev Med. Volume: 17 Issue: 5 Pages: 408-14
  • DOI: 10.1007/s12199-012-0270-1
  • NAID: 10031120515
  • Peer Reviewed
• [Journal Article] Serum neurofilament concentrations in children with prolonged febrile seizures (2012)
  • Author(s): Matsushige T, Inoue H, Fukunaga S, Hasegawa S, Okuda M, Ichiyama T.
  • Journal Title: Journal of Neurological Science Volume: 321 Issue: 1-2 Pages: 39-42
  • DOI: 10.1016/j.jns.2012.07.043
  • Peer Reviewed