Comparative epidemiological study for the effect of exercise by gene polymorphism among general population

• Project/Area Number: 24590750
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene
• Research Institution: Kagoshima University
• Principal Investigator: TAKEZAKI Toshiro 鹿児島大学, 医歯(薬)学総合研究科, 教授 (50227013)
• Co-Investigator(Kenkyū-buntansha): 新村 英士 鹿児島大学, 医歯(薬)学総合研究科, 講師 (80381177)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 運動 / 日常身体活動 / 海洋療法 / 医療費 / 遺伝子多型 / 動脈硬化 / ホモシステイン / 葉酸 / 高血圧

Outline of Final Research Achievements

To investigate the effect of exercise by gene polymorphism, we conducted comparative epidemiological study using daily activity, habitual exercise and thalassotherapy as exposure; and medical cost and death risk as outcome. The subjects were general population living in an island of Kagoshima with thalassotherapy facility who had routine health checkup (n=445).
Frequent use of thalassotherapy that includes exercise in sea water was associated with decreased medical cost among those with hypertension, when medical cost was compared between the first 3- year and the second 3-year. The decrease in medical cost was also observed among those with higher susceptibility for developing obesity that was shown as beta-2 and beta-3 adrenoceptor genes.

Research Products

• [Journal Article] Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study. (2012)
  • Author(s): Hishida A, Morita E, Naito M, Okada R, Wakai K, Matsuo K, Nakamura K, Takashima N, Suzuki S, Takezaki T, Mikami H, Ohnaka K, Watanabe Y, Uemura H, Kubo M, Tanaka H, Hamajima N
  • Journal Title: Endocr J Volume: 59 Pages: 589-599
  • NAID: 10031064281
  • Peer Reviewed
• [Presentation] 日常身体活動量や運動習慣、海洋療法によるる動脈硬化要因及び医療費の改善に関する研究 (2013)
  • Author(s): 嶋谷圭一，桑原和代，新村英士，中村昭彦，立棒雅也，小川信，中畑典子，Motahare Kheradmand， Mantjoro Eva Mariane，根路銘安仁，大脇哲洋、草野健，嶽崎俊郎
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] Effect of MTHFR polymorphism for homocysteine levels and arterial stiffness by food intake
  • Author(s): Eva Mariane Mantjoro, Hideshi Niimura, Kazuyo Kuwabara, Hiroaki Kanouchi, Kusuke Toyoda, Motahare Kheradmand, Akihiko Nakamura, Shin Ogawa, Noriko Nakahata, Yasuhito Nerome, Tetsuhiro Ohwaki, Ken Kusano and Toshiro Takezaki
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 仙台
• [Presentation] あまみ島嶼地域における末梢動脈疾患の分布と要因に関する研究
  • Author(s): 桑原和代、新村英士、中村昭彦、中畑典子、Motahare Kheradmand、 Mantjoro Eva Mariane、嶋谷圭一、小川信、根路銘安仁、大脇哲洋、草野健、杉山大典、岡村智教、嶽崎俊郎
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 仙台
• [Book] The Islands of Kagoshima. In: Kawai K, Terada R, Kuwahara S, eds. (2013)
  • Author(s): Takezaki T, Niimura H, Kuwabara K
  • Publisher: The Islands of Kagoshima Kagoshima University Research Center