The study on the neurotoxic effects of tributyltin on F1 Tokai High Avoider rats
| Project/Area Number |
24590756
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHIRA Shuji 獨協医科大学, 医学部, 教授 (10118466)
WATANABE Tetsu 東海大学, 医学部, 教授 (10129744)
ENDO Hitoshi 東海大学, 医学部, 講師 (10550551)
TASHIRO Tomoko 青山学院大学, 理工学部, 教授 (50114541)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | トリブチルスズ / 神経毒性 / F1ラット / Tokai High Avoiderラット / シドマン電撃回避試験 / オープンフィールド試験 / 二世代曝露 / 高学習能ラット / Prepulse inhibition test / ２世代曝露 / 発達神経毒性 / THA ラット / 記憶学習能力 / オープンフィールド / シドマン回避試験 / 経胎盤曝露 / 経母乳曝露 |
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| Outline of Final Research Achievements |
The neurotoxic effects of tributyltin (TBT) on the F1 Tokai High Avoider rats which achieved high learning ability were evaluated by the Sidman electric shock avoidance test and open field test. The F1 rats were exposed to TBT via the placenta, their dams' milk and/or their food or via their food only. The mean values of body weight in the TBT-exposed rats were significantly lower than those of respective control. The avoidance rates of the TBT-exposed rats in the Sidman electric shock avoidance test were significantly lower than those in the control. The locomotor distance of the TBT-exposed rats in the open field test were significantly lower than the respective control over the several time intervals. The number of wall rearing of the TBT-exposed rats were also significantly lower than that of the respective control. The neurotoxic effects were most evident when the rats were exposed to TBT via the placenta, their dams' milk and their food.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Evaluation of neurotoxicity of artificial dura mater and poly(lactic-glycolic acid-caprolactone) co-oligomer containing dibutyltin or tin (II) octylate in rats.2013
Author(s)
Tsuji, M., Tsunoda, M., Sugaya, C., Inoue, Y., Hirano, S., Katagiri, H., Akita, H., Saji, M., Yuba, T., Fukushima, T., Tsuchiya, T. and Aizawa, Y.
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Journal Title
Biomedical Research on Trace Elements
Volume: 24
Pages: 153-162
NAID
Related Report
Peer Reviewed
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[Journal Article] Exposure to tributyltin (TBT) via food during developmental stages after weaning, or the exposure via the placenta and their dams’ milk, inhibits body weight gain and behaviors in rats.2012
Author(s)
Ikeuchi, R., Kido, T., Sugaya, C., Katagiri, H., Akita, H., Saji, M., Tsunoda, M. and Aizawa, Y.
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Journal Title
The Kitasato Medical Journal
Volume: 42
Pages: 57-66
Related Report
Peer Reviewed
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[Presentation] The impairment of learning ability of male F1 Tokai High Avoider rats exposed to tributyltin via the placenta, their dams’ milk, and their food.2015
Author(s)
Tsunoda, M., Kajiwara, K., Hasegawa, T., Kido, T., Hosokawa, M., Sugaya, C., Sugiura, Y., Horiguchi, H., Endo, H. and Watanabe, T.
Organizer
54th Annual Meeting of Society of Toxicology
Place of Presentation
San Diego convention center (San Diego, CA, USA)
Year and Date
2015-03-21 – 2015-03-26
Related Report
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[Presentation] The neurotoxic effects of tributyltin on male F1 Tokai High Avoider (THA) rats evaluated by the Sidman electric shock avoidance test.2014
Author(s)
Tsunoda, M., Hasegawa, T., Kido, T., Hosokawa, M., Sugaya, C., Sugiura, Y., Endo, H. and Watanabe, T.
Organizer
Society of Toxicology, 53rd Annual Meeting and ToxExpo
Place of Presentation
米国アリゾナ州フェニックス
Related Report
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[Presentation] Locomotor distance of male Tokai High Avoider rats exposed to tributyltin via the placenta and their dams’ milk.2013
Author(s)
Tsunoda, M., Hasegawa, T., Sugaya, C., Sugiura, Y., Kido, T., Hosokawa, M., Endo, H., Wataanbe, T. and Aizawa, Y.
Organizer
第23回金属の関与する生体関連反応シンポジウム
Place of Presentation
東京都三鷹市
Related Report
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[Presentation] The neurotoxic effects of tributyltin on Tokai High Avoider (THA) rats evaluated by Sidman electric shock avoidance test.2013
Author(s)
Tsunoda, M., Kido, T., Hosokawa, M., Sugaya, C., Endo, H., Watanabe, T. and Aizawa, Y.
Organizer
Society of Toxicology, 52nd Annual Meeting
Place of Presentation
米国テキサス州サンアントニオ
Related Report
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