| Project/Area Number |
24590758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Keio University |
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Principal Investigator |
NAKANO Makiko 慶應義塾大学, 医学部, 講師 (70384906)
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| Co-Investigator(Renkei-kenkyūsha) |
OMAE Kazuyuki 慶應義塾大学, 医学部, 教授 (60118924)
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| Research Collaborator |
TANAKA Akiyo 九州大学, 医学研究院, 講師 (10136484)
HIRATA Miyuki 九州大学, 医学研究院, 助教 (30156674)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | インジウム / 肺機能 / 肺拡散能 / 胸部CT / 妥当性 / 肺機能検査 |
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| Outline of Final Research Achievements |
During the study period, we performed health checks on indium-exposed workers and measured diffuse lung capacity (DLco) as an effect marker of pulmonary function using a portable-type machine. After validity assessment of DLco with Quality Grade A-C (n=213), Spearman’s correlation coefficient was conducted between DLCO and scores of emphysematous change or interstitial change on High-Resolution CT (HRCT) (n=48). Correlation coefficients (r) were -0.320 (emphysematous change and DLco), -0.412 (emphysematous change and %DLco) and -0.386 (emphysematous change and %DLco/VA). The correlation between emphysematous change on HRCT and %DLco was higher than that between interstitial change on HRCT and %DLco. Results suggested that DLco, %DLco and %DLco/VA in indium-exposed workers were effective markers for emphysema.
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