| Project/Area Number |
24590763
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Kawada Tomoyuki 日本医科大学, 医学(系)研究科(研究院), 教授 (00224791)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA TOSHIAKI 日本医科大学, 医学部, 准教授 (80339374)
INAGAKI HIROFUMI 日本医科大学, 医学部, 講師 (50213111)
WAKAYAMA YOKO 日本医科大学, 医学部, 講師 (40104062)
KATSUMATA MASAO 日本医科大学, 医学部, 助教 (80169482)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | メンタルヘルス / メタボリックシンドローム / 職場労働者 / インスリン抵抗性 / 生活習慣 / 発症率 / 予防 / 心理的安寧 / 睡眠時間 / インスリン / メタボリック症候群 / C反応タンパク / リスク評価 / 労働者 |
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| Outline of Final Research Achievements |
Male workers, aged from 35 to 60 years old, were recruited in this study to know the association between mental health and metabolic syndrome (MetS). Cross-sectional and one-year follow-up studies were set for the analysis. The number of participants was 3,639 people without MetS-related disease. Mental status was evaluated by General Health Questionnaire 12-item version (GHQ12), and serum insulin and serum high sensitive C-reactive protein (CRP) were used as biological markers. Logistic regression analysis was mainly used for the analysis. Prevalence rate of MetS was 16.4% in the cross-sectional study, and the associated factors with MetS were serum insulin, serum high sensitivity CRP, age and GHQ12. One-year follow-up study for incident MetS was also conducted and the incidence rate was 8.8%. Predictors for MetS were age, serum uric acid, serum ALT, serum high sensitivity CRP and a marker of insulin resistance. In addition, regular exercise was a protective factor for incident MetS.
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