| Project/Area Number |
24590765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Yasuhiro 日本医科大学, 医学部, 助教 (20350077)
INAGAKI Hirofumi 日本医科大学, 医学部, 講師 (50213111)
KAWADA Tomoyuki 日本医科大学, 大学院医学研究科, 教授 (00224791)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 非対称性ジメチルアルギニン / メタボリック症候群 / 疫学研究 / 脳卒中 / 高血圧 / 高コレステロール血症 / C反応性蛋白 / プラバスタチン / 生活習慣病 / 危険因子 / 予防医学 |
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| Outline of Final Research Achievements |
We measured serum asymmetric dimethylarginine (ADMA) levels in male workers who underwent annual health examination. The ADMA levels were associated with age and several lifestyle-related diseases such as blood pressure and lipid profiles, as well as the predicted risk of stroke. However, the ADMA levels did not predict the future onset of the metabolic syndrome. The administration of cholesterol-lowering drug reduced the risk of incident hypertension in patients with hypercholesterolemia.
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