| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Molecular hydrogen (H2) is an agent with potential applications in oxidative stress-related and/or inflammatory disorders. In this study, we investigated whether H2 attenuates UV-induced tissue injury. We first demonstrated that H2 protected Caenorhabditis elegans from high-dose UV exposure and extends its lifespan. We next examined whether H2 modified the history of UV-induced skin tumors in hairless mice and found that H2 delayed skin tumor development in its early phase. We also found that H2 repressed UV-induced skin inflammation, suggesting that modified skin inflammation may lead to delayed onset of UV-induced skin tumors. Therefore, we concluded that H2 may prevent UV-induced tissue injury including UV-induced malignant skin tumors.
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