Molecular hydrogen attenuates UV-induced tissue injury in Caenorhabditis elegans and mouse
Project/Area Number |
24590768
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hygiene
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Research Institution | Chubu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MURAKUMO Yoshiki 北里大学, 医学部, 教授 (40324438)
SOBUE Sayaka 中部大学, 臨床検査技術教育・実習センター, 助教 (50513347)
IWAMOTO Takashi 中部大学, 生命健康科学部, 教授 (60223426)
|
Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 分子状水素 / 紫外線 / 皮膚癌 / 線虫 / 炎症 / 水素 / 酸化ストレス / 扁平上皮癌 / 発癌 |
Outline of Final Research Achievements |
Molecular hydrogen (H2) is an agent with potential applications in oxidative stress-related and/or inflammatory disorders. In this study, we investigated whether H2 attenuates UV-induced tissue injury. We first demonstrated that H2 protected Caenorhabditis elegans from high-dose UV exposure and extends its lifespan. We next examined whether H2 modified the history of UV-induced skin tumors in hairless mice and found that H2 delayed skin tumor development in its early phase. We also found that H2 repressed UV-induced skin inflammation, suggesting that modified skin inflammation may lead to delayed onset of UV-induced skin tumors. Therefore, we concluded that H2 may prevent UV-induced tissue injury including UV-induced malignant skin tumors.
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells.2016
Author(s)
Mizutani N, Omori Y, Kawamoto Y, Sobue S, Ichihara M, Suzuki M, Kyogashima M, Nakamura M, Tamiya-Koizumi K, Nozawa Y, Murate T.
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Journal Title
Biochem Biophys Res Commun
Volume: 470
Issue: 4
Pages: 851-856
DOI
Related Report
Peer Reviewed
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[Journal Article] Detection of a Soluble Form of CD109 in Serum of CD109 Transgenic and Tumor Xenografted Mice.2014
Author(s)
Sakakura H, Murakumo Y, Mii S, Hagiwara S, Kato T, Asai M, Hoshino A, Yamamoto N, Sobue S, Ichihara M, Ueda M, Takahashi M.
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Journal Title
PLoS One
Volume: 9
Issue: 1
Pages: e83385-e83385
DOI
Related Report
Peer Reviewed
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[Journal Article] Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB.2013
Author(s)
Mizutani N, Kobayashi M, Sobue S, Ichihara M, Ito H, Tanaka K, Iwaki S,Fujii S,Ito Y, Tamiya-Koizumi K, Takagi A, Kojima T, Naoe T, Suzuki M, Nakamura M, Banno Y, Nozawa Y, Murate T.
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Journal Title
Biochimica et Biophysica Acta -Molecular Cell Research
Volume: 1833
Issue: 5
Pages: 1006-16
DOI
Related Report
Peer Reviewed
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[Journal Article] Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109.2012
Author(s)
Mii S, Murakumo Y, Asai N, Jijiwa M, Hagiwara S, Kato T, Asai M, Enomoto A, Ushida K, Sobue S, Ichihara M, Takahashi M.
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Journal Title
Am J Pathol
Volume: 181
Issue: 4
Pages: 1180-1189
DOI
Related Report
Peer Reviewed
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