| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
We analyzed 56 single nucleotide polymorphisms (SNPs) identified in previous GWASs and conducted a case-control study with 697 case subjects and 1,394 age- and menopausal status-matched controls within the framework of Hospital-based Epidemiological Research Program at Acihi Cancer Center. Among 56 SNPs, 23 was selected to built a risk prediction model for breast cancer. We evaluated the prediction models using AUC (Area Under the Curve) in receiver-operating characteristic (ROC). The AUC for a model including the genetic risk score in addition to the conventional risk factors was 0.726, versus 0.675 with the conventional risk factors only (P <0.05). In conclusion, we identified a genetic risk predictor of breast cancer in a Japanese population. Identification of additional new loci in the GWASs among Asian or Japanese populations is needed to establish more accurate risk prediction model.
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