To detect the environmental risk factors relating to developmental disorder in school-children and prevention used nested case-control study.
| Project/Area Number |
24590777
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Hokkaido University |
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Principal Investigator |
IKENO Tamkio 北海道大学, 環境健康科学研究教育センター, 特任講師 (80569715)
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| Co-Investigator(Kenkyū-buntansha) |
MUROHASHI Harumitsu 北海道大学, 大学院教育学研究院, 教授 (00182147)
SHIRAISHI Hideaki 北海道大学, 北海道大学病院, 助教 (80374411)
SASAKI Seiko 北海道大学, 大学院医学研究院, 助教 (30448831)
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| Co-Investigator(Renkei-kenkyūsha) |
KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)
ARAKI Atsuko 北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)
AZUMI Kaoru 北海道大学, 北海道大学病院, 特任講師 (90221720)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 発達障害 / ADHD / 学童期 / 喫煙曝露 / 環境遺伝交互作用 / 疫学 / 環境リスク |
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| Outline of Final Research Achievements |
In this study, we examined the effects of environmental factors on risk of attention hyperactivity diorder (ADHD) in a prospective birth cohort with more than 20,000 participants. 1)We assessed the effects of smoking exposure during pregnancy and at age 7 years old, using ADHD rating scale (ADHD-RS). We found that home environment and maternal depression have more effects on ADHD-RD than smoking exposure. 2)We determined IQ of 179 children using WISC-IV test in a nested case -control study. 3) We investigated single nucleotide polymorphisms(SNPs) of neurotransmitter related gene （DRD4,DAT1,HTR1B,COMT,SNAP25）and brain-derived neurotrophic factor （BDNF）by EP1 system (Fludigm)in ADHD-suspected and control groups. We have finished SNPs determination in 200 subjects of 390 statistical power.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women2013
Author(s)
Kobayashi S, Sata F, Sasaki S, Ban S, Miyashita C, Okada E, Limpar M, Yoshioka E, Kajiwara J, Todaka T, Saijo Y, Kishi R
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Journal Title
Toxicology Letters
Volume: 219(3)
Issue: 3
Pages: 269-278
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Ten years of progress in the Hokkaido birth cohort study on environment and children's health : cohort profile--updated 2013.2013
Author(s)
Kishi R, Kobayashi S, Ikeno T, Araki A, Miyashita C, Itoh S, Sasaki S, Okada E, Kobayashi S, Kashino I, Itoh K, Nakajima S ; Members of the Hokkaido Study on Environment and Children's Health.
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Journal Title
Environmental Health and Preventive Medicine
Volume: 18
Issue: 6
Pages: 429-450
DOI
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Peer Reviewed
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[Presentation] The effects of perfluoroalkyl acids (PFAAs) exposure in utero on IGF2/H19 DNA methylation in cord blood.2014
Author(s)
Kobayashi S., Azumi K., Sasaki S., Ishizuka M., Nakazawa H., Okada E., Kobayashi S., Goudarzi H., Itoh S., Miyashita C., Ikeno T., Araki A., Kishi R.
Organizer
26th Annual International Society for Environmental Epidemiology Conference
Place of Presentation
University of Washington, Seattle, USA.
Year and Date
2014-08-24 – 2014-08-28
Related Report
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[Presentation] 児の出生体重と母親の社会経済要因との関連についての疫学研究2014
Author(s)
田村菜穂美, 伊藤久美子, 小林澄貴, 岡田恵美子, 喜多歳子, Goudarzi Houman, 宮下ちひろ, 荒木敦子, 池野多美子, 岸玲子
Organizer
第84回 日本衛生学会学術総会.
Place of Presentation
岡山コンベンションセンター（岡山県・岡山市）
Year and Date
2014-05-25 – 2014-05-27
Related Report
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[Presentation] Research plan for 7 year-old survey of the Hokkaido Study2012
Author(s)
Araki A, Miyashita C, Ikeno T, Sasaki S, Tajima S, Ait Bamai Y, Cong Shi, Ukawa S, Kawai T, Tsuboi T, Okada E, Kishi R
Organizer
Birth Cohort Consortium in Asia:BiCCA2012
Place of Presentation
Natioanl Taiwan University (China)
Related Report
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