| Project/Area Number |
24590777
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Hokkaido University |
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Principal Investigator |
IKENO Tamkio 北海道大学, 環境健康科学研究教育センター, 特任講師 (80569715)
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| Co-Investigator(Kenkyū-buntansha) |
MUROHASHI Harumitsu 北海道大学, 大学院教育学研究院, 教授 (00182147)
SHIRAISHI Hideaki 北海道大学, 北海道大学病院, 助教 (80374411)
SASAKI Seiko 北海道大学, 大学院医学研究院, 助教 (30448831)
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| Co-Investigator(Renkei-kenkyūsha) |
KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)
ARAKI Atsuko 北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)
AZUMI Kaoru 北海道大学, 北海道大学病院, 特任講師 (90221720)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 発達障害 / ADHD / 学童期 / 喫煙曝露 / 環境遺伝交互作用 / 疫学 / 環境リスク |
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| Outline of Final Research Achievements |
In this study, we examined the effects of environmental factors on risk of attention hyperactivity diorder (ADHD) in a prospective birth cohort with more than 20,000 participants. 1)We assessed the effects of smoking exposure during pregnancy and at age 7 years old, using ADHD rating scale (ADHD-RS). We found that home environment and maternal depression have more effects on ADHD-RD than smoking exposure. 2)We determined IQ of 179 children using WISC-IV test in a nested case -control study. 3) We investigated single nucleotide polymorphisms(SNPs) of neurotransmitter related gene （DRD4,DAT1,HTR1B,COMT,SNAP25）and brain-derived neurotrophic factor （BDNF）by EP1 system (Fludigm)in ADHD-suspected and control groups. We have finished SNPs determination in 200 subjects of 390 statistical power.
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