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The study for biological future of the interval cancers detected in mammography screening.

Research Project

Project/Area Number 24590781
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionTohoku University

Principal Investigator

Suzuki Akihiko  東北大学, 医学(系)研究科(研究院), 准教授 (60375045)

Co-Investigator(Kenkyū-buntansha) Ishida TAKANORI  東北大学, 医学系研究科, 准教授 (00292318)
Umeda MIKA  東北大学, 医学系研究科, 准教授 (20292344)
Ohuchi NORIAKI  東北大学, 医学系研究科, 教授 (90203710)
河合 賢朗  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), その他部局等, 研究員 (80513530)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords乳がん検診 / マンモグラフィ / 中間期がん / 超音波 / 超音波検査 / 総合判定 / マンモグラフィー / 精度管理 / 癌がん登録 / J-START
Outline of Final Research Achievements

Although mammography is the only method that has evidence supporting mortality reduction for breast cancer, accuracy is reduced in women with high-density breast tissue and in young women. We have continued the study for interval caner for a decade. The article about the primary endpoint of “the Japan Strategic Anti-cancer Randomized Trial (J-START)”was published in the Lancet in January 2016. Interval cancers were reported as 35 in the control group and 18 in the intervention group. Interval cancers, which were detected in the intervention group, were significantly lower then control group. We are continuing analyze the biological future of the interval cancers.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results)

  • [Journal Article] Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial.2016

    • Author(s)
      Ohuchi N., Suzuki A., Sobue T., Kawai M., Yamamoto S., Zheng Y. F., Shiono Y. N., Saito H., Kuriyama S., Tohno E., Endo T., Fukao A., Tsuji I., Yamaguchi T., Ohashi Y., Fukuda M., Ishida T
    • Journal Title

      The Lancet

      Volume: 387 Issue: 10016 Pages: 341-348

    • DOI

      10.1016/s0140-6736(15)00774-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] J-STARTはどのようにおこなわれたか ―大規模RCTの企画、運営、集計の経験― 3.研究組織作り、組織構成、CRC養成2016

    • Author(s)
      鈴木昭彦、石田孝宣、成川洋子、鄭 迎芳、大内憲明
    • Journal Title

      日本乳癌検診学会誌

      Volume: 不明

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Controversies in breast cancer screening for women aged 40-49 years.2014

    • Author(s)
      Suzuki A, Ishida T, Ohuchi N.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 44 Pages: 613-618

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Controversies in breast cancer screening for women aged 40-49 years.2014

    • Author(s)
      Suzuki A, Ishida T, Ohuchi N
    • Journal Title

      Jpn J Clin Oncol.

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Randomized Controlled Trial to Verify the Efficacy of the Use of Ultrasonography in Breast Cancer Screening Aged 40-49 (J-START): 76 196 Women Registered2013

    • Author(s)
      Ishida T, Sobue T, et al
    • Journal Title

      Jpn J Clin Oncol

      Volume: 44 Issue: 2 Pages: 134-140

    • DOI

      10.1093/jjco/hyt199

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of screening mammography on cumulative survival of Japanese women aged 40-69 years with breast cancer2012

    • Author(s)
      Kawai M. Suzuki A. Nishino Y. Ohnuki K. Ishida T. Amari M. Shibuya D. Ohuchi N.
    • Journal Title

      Breast Cancer

      Volume: - Issue: 5 Pages: 542-549

    • DOI

      10.1007/s12282-012-0434-2

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 実現可能で有効な乳癌検診 ―仙台市乳がん検診で出来たことと今後の課題―2012

    • Author(s)
      鈴木昭彦、石田孝宣、甘利正和、多田寛、渡部剛、玉城研太朗、大内憲明
    • Journal Title

      日本乳癌検診学会誌

      Volume: 21(3) Pages: 17-22

    • NAID

      130004701777

    • Related Report
      2012 Research-status Report
  • [Presentation] The result of J-START, a randomized controlled trial to verify the efficacy of the use of US in breast cancer screening aged 40-492015

    • Author(s)
      Akihiko Suzuki, Takanori Ishida, Noriaki Ohuchi
    • Organizer
      Gachon Breast Imaging Forum
    • Place of Presentation
      Gachon, Korea
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] J-STARTはどのようにおこなわれたか ―大規模RCTの企画、運営、集計の経験― 3.研究組織作り、組織構成、CRC養成2015

    • Author(s)
      鈴木昭彦、石田孝宣、成川洋子、鄭 迎芳、大内憲明
    • Organizer
      第25回日本乳癌検診学会
    • Place of Presentation
      つくば市(つくば国際会議場)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Ultrasound Breast Cancer Screening. What should we learn from J-START.2015

    • Author(s)
      Akihiko Suzuki, Takanori Ishida, Noriaki Ohuchi
    • Organizer
      The 23rd Annual Meeting of the Japanese Breast Cancer Society Asian exchange forum US screening in Asia
    • Place of Presentation
      Tokyo(東京国際フォーラム)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マンモグラフィでカテゴリー3の腫瘤の意義を考える2015

    • Author(s)
      鈴木昭彦、石田孝宣、多田寛、渡部剛、宮下穣、原田成美、佐藤章子、大内憲明
    • Organizer
      第23回日本乳癌学会総会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] マンモグラフィ検診ソフトコピー診断の現状と問題点2014

    • Author(s)
      鈴木昭彦、石田孝宣、大内憲明 他
    • Organizer
      10.第24回日本乳癌検診学会学術総会
    • Place of Presentation
      前橋市(ベイシア文化ホール)
    • Year and Date
      2014-11-07 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Randomized Controlled Trial to Verify the Efficacy of Ultrasonography for Breast Cancer Screening: Up-dated Data from the J-START.2014

    • Author(s)
      3.Suzuki A.
    • Organizer
      11th International Conference of the Asian Clinical Oncology Society.
    • Place of Presentation
      Taipei, Taiwan.
    • Year and Date
      2014-05-02 – 2014-05-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] マンモグラフィ検診における視触診の意義に関する検討2013

    • Author(s)
      鈴木昭彦、石田孝宣、多田寛、渡部剛、藤井里圭、大内憲明
    • Organizer
      第21回 日本乳癌学会総会
    • Place of Presentation
      浜松市
    • Related Report
      2013 Research-status Report
  • [Presentation] J-STARTの現状と今後の課題2012

    • Author(s)
      鈴木昭彦、石田孝宣、河合賢朗、成川洋子、大内憲明
    • Organizer
      日本乳癌検診学会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Research-status Report
    • Invited

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Published: 2013-05-31   Modified: 2019-12-18  

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