| Project/Area Number |
24590797
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kyushu University |
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Principal Investigator |
DOI Yasufumi 九州大学, 医学(系)研究科(研究院), 研究員 (00419566)
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| Co-Investigator(Kenkyū-buntansha) |
KUBO Michiaki 独立行政法人理化学研究所, 横浜研究所ゲノム医科学研究センター, 副センター長 (30442958)
KIYOHARA Yutaka 九州大学, 医学部, 教授 (80161602)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | インスリン分泌 / 追跡研究 / 遺伝子多型 / 長期追跡 / 肥満 / BMI / SNPｓ / KCNQ1 / CDC123,CAMK1D / ゲノム / 糖尿病 / 疫学 |
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| Outline of Final Research Achievements |
Objective: Few prospective studies have examined the association of environmental and genetic factors with the potential of insulin secretion in the general population. Methods: A total of 2,074 community-dwelling Japanese individuals aged 40 and more without diabetes were followed up for 5 years. In the baseline survey, age, sex, body mass index (BMI), exercise, drinking, smoking, glomerular filtration rate, and total cholesterol, and a total of 36 SNPs of 27 loci SNPs derived from GWAS of diabetes were measured. Results: In the clinical factors, the significant association between BMI levels and time-dependent change of insulin secretion was observed. Furthermore, the age-, sex-, and BMI-adjusted analyses showed the significant associations between the rs2283228 (KCNQ1) as well as the rs12779790 (CDC123,CAMK1D) genes and time-dependent change of insulin secretion. In conclusion, BMI levels and two SNPs were related to the time-dependent potential of insulin secretion.
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