Longitudinal study of insulin secretion taking into account genetic and environmental factors in a general population: the Hisayama Study
Project/Area Number |
24590797
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Public health/Health science
|
Research Institution | Kyushu University |
Principal Investigator |
DOI Yasufumi 九州大学, 医学(系)研究科(研究院), 研究員 (00419566)
|
Co-Investigator(Kenkyū-buntansha) |
KUBO Michiaki 独立行政法人理化学研究所, 横浜研究所ゲノム医科学研究センター, 副センター長 (30442958)
KIYOHARA Yutaka 九州大学, 医学部, 教授 (80161602)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | インスリン分泌 / 追跡研究 / 遺伝子多型 / 長期追跡 / 肥満 / BMI / SNPs / KCNQ1 / CDC123,CAMK1D / ゲノム / 糖尿病 / 疫学 |
Outline of Final Research Achievements |
Objective: Few prospective studies have examined the association of environmental and genetic factors with the potential of insulin secretion in the general population. Methods: A total of 2,074 community-dwelling Japanese individuals aged 40 and more without diabetes were followed up for 5 years. In the baseline survey, age, sex, body mass index (BMI), exercise, drinking, smoking, glomerular filtration rate, and total cholesterol, and a total of 36 SNPs of 27 loci SNPs derived from GWAS of diabetes were measured. Results: In the clinical factors, the significant association between BMI levels and time-dependent change of insulin secretion was observed. Furthermore, the age-, sex-, and BMI-adjusted analyses showed the significant associations between the rs2283228 (KCNQ1) as well as the rs12779790 (CDC123,CAMK1D) genes and time-dependent change of insulin secretion. In conclusion, BMI levels and two SNPs were related to the time-dependent potential of insulin secretion.
|
Report
(4 results)
Research Products
(32 results)
-
-
[Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study.2014
Author(s)
Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
-
Journal Title
Atherosclerosis
Volume: 233
Issue: 2
Pages: 343-348
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study.2014
Author(s)
Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y.
-
Journal Title
J Diabetes Invest
Volume: 5
Issue: 2
Pages: 162-169
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study.2013
Author(s)
Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y.
-
Journal Title
Cardiovascular Diabetology
Volume: 12
Pages: 164-164
Related Report
Peer Reviewed
-
[Journal Article] Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study.2013
Author(s)
Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, Kitazono T, Kanba S, Kiyohara Y.
-
Journal Title
BMC Public Health
Volume: 13
Pages: 862-862
Related Report
Peer Reviewed
-
-
[Journal Article] Magnesium intake decreases type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study.2013
Author(s)
Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J, Ozawa M, Uchida K, Shirota T, Kitazono T, Kiyohara Y.
-
Journal Title
Diabet Med
Volume: 30
Issue: 12
Pages: 1487-1494
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama study.2013
Author(s)
Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.
-
Journal Title
Stroke
Volume: 44
Pages: 1512-1517
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article] Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama Study2012
Author(s)
Ozawa, M. Ninomiya, T. Ohara, T. Hirakawa, Y. Doi, Y. Hata, J. Uchida, K. Shirota, T. Kitazono, T. Kiyohara, Y.
-
Journal Title
J Am Geriatr Soc
Volume: 60
Issue: 8
Pages: 1515-1520
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Presentation] 地域住民におけるangiopoietin-like protein 2と2型糖尿病の発症リスク:久山町研究2012
Author(s)
土井康文, 二宮利治, 平川洋一郎, 高橋音羽, 向井直子, 秦 淳, 永田雅治, 福原正代, 岩瀬正典, 北園孝成, 尾池雄一, 清原 裕
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
東京
Related Report
-
-
-
-