Impact of the introduction of Haemophilus influenzae type b conjugate vaccine against childhood pneumonia in Vietnam

• Project/Area Number: 24590798
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Nagasaki University
• Principal Investigator: SUZUKI Motoi 長崎大学, 熱帯医学研究所, 助教 (60444874)
• Co-Investigator(Renkei-kenkyūsha): YOSHIDA Laymyint 長崎大学, 熱帯医学研究所, 教授 (90432963)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: インフルエンザ桿菌ｂ型 / インフルエンザ桿菌ｂ型ワクチン / 小児肺炎 / ベトナム / ワクチン / 国際情報交換 / 小児感染症

Outline of Final Research Achievements

Despite the global success of Hib vaccination in reducing disease and mortality, uncertainty about the disease burden and the potential impact of Hib vaccination in Southeast Asia has delayed the introduction of vaccination in some countries in the region. Hib vaccination was introduced throughout Vietnam in July 2010 without catch-up. In an observational, population based surveillance study we estimated the impact of routine Hib vaccination on all cause radiologically confirmed childhood pneumonia in Vietnam. The adjusted annual incidence of pneumonia in children younger than 5 years declined by 39% (12-58%) after introduction of Hib vaccination.

Research Products

• [Journal Article] Early indication for a reduced burden of radiologically confirmed pneumonia in children following the introduction of routine vaccination against Haemophilus influenzae type b in Nha Trang, Vietnam. (2014)
  • Author(s): Flasche S, Takahashi K, Vu DT, Suzuki M, Nguyen TH, Le H, Hashizume M, Dang DA, Edmond K, Ariyoshi K, Mulholland EK, Edmunds WJ, Yoshida LM.
  • Journal Title: Vaccine Volume: 32 Issue: 51 Pages: 6963-6970
  • DOI: 10.1016/j.vaccine.2014.10.055
  • Peer Reviewed
• [Journal Article] Impact of 2009 pandemic influenza among Vietnamese children based on a population-based prospective surveillance from 2007 to 2011. (2014)
  • Author(s): Le MN, Yoshida LM, Suzuki M, Nguyen HA, Le HT, Moriuchi H, Dang DA, Ariyoshi K.
  • Journal Title: Influenza and Other Respir Viruses Volume: 12244 Issue: 4 Pages: 1-8
  • DOI: 10.1111/irv.12244
  • NAID: 120006986547
  • Peer Reviewed
• [Journal Article] Incidence of radiologically-confirmed pneumonia and Haemophilus influenzae type b carriage before Haemophilus influenzae type b conjugate vaccine introduction in Central Vietnam. (2013)
  • Author(s): Yoshida LM, Nguyen HA, Watanabe K, Le MN, Nguyen AT, Vu HT, Yoshino H, Suzuki M, Takahashi K, Le T, Moriuch H, Kilgore PE, Edmond K, Mulholland K, Dang DA, Ariyoshi K.
  • Journal Title: Journal of Pediatrics Volume: 163 Issue: 1 Pages: S38-S43
  • DOI: 10.1016/j.jpeds.2013.03.029
  • Peer Reviewed