| Project/Area Number |
24590812
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Bunkyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Miki 文教大学, 健康栄養学部, 講師 (20331457)
MEKATA Yuko 文教大学, 健康栄養学部, 講師 (60617281)
FUJIMI Takahiko 文教大学, 健康栄養学部, 准教授 (80322452)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ヒスチジン / 抗肥満 / コレステロール / イソフラボン / 大豆 |
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| Outline of Final Research Achievements |
Suppressive effect of histidine on obesity seems to be increased by steroid hormone. This study focused on the cholesterol that is the precursor of steroid hormone, isoflavon that has the similar effect of steroid hormone, and soybean foods that contain much amount of isoflavone. The aim of this study is to clarify the influence of cholesterol, isoflavone, soybean foods for the suppressive effect of histidine on obesity. From the results of nutrition survey of human, the suppressive effect of histidine on obesity seemed to be increased by the oral administration of cholesterol and soybean foods. Also from the animal experiments using rats, the oral administration of isoflavon seemed to increase the suppressive effect of histidine on food intake and accumulation of body fat. These results suggest that the suppressive effect of histidine on obesity seems to be increased by the oral administration of cholesterol, isoflavon, and soybean foods.
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