| Project/Area Number |
24590820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORINOBU Shigeru 高知大学, 医歯学系, 教授 (30191042)
YOSHIDA Hideyo 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (00242735)
OBUCHI Shuichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究副部長 (50265740)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 疫学 / 大うつ病性障害 / うつ尺度 / 地域精神保健 / 脳由来神経栄養因子（BDNF) / エピジェネティクス / メチル化障害 / 後期高齢者 / 小うつ病性障害 / BDNF / 高齢者 / SCID / GRID-HAMD / DNAメチル化障害 |
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| Outline of Final Research Achievements |
Primary and secondary prevention of depression among the elderly is a crucial challenge of public health services. The purpose of this study is to investigate a role of epigenetics in the pathology of depressive disorders among the elderly and to develop a biological screening tool for depression using epigenetic methods. Our cross-sectional study explored that methylation rates of some CpG units at the promoters of the brain-derived neurotrophic factor (BDNF) gene were higher in elderly persons with major depressive disorder than in healthy controls.
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