Epidemiological Study on the Association of Obesity-Related and Diabetes-Related Genes with Colorectal Adenoma

• Project/Area Number: 24590830
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: National Cancer Center Japan
• Principal Investigator: YAMAJI Taiki 独立行政法人国立がん研究センター, がん予防・検診研究センター, 室長 (10466203)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 大腸腺腫 / 肥満関連遺伝子 / 糖尿病関連遺伝子 / 分子疫学研究 / ハプロタイプ

Outline of Final Research Achievements

Supported by Grant-in-Aid for Scientific Research C, this researcher conducted an epidemiological study on the association of obesity-related and diabetes-related genes with colorectal adenoma. No association was observed for 9 single nucleotide polymorphisms selected form one obesity-related gene (FTO) and two diabetes-related genes (TCF7L2 and KCNQ1) in relation to colorectal adenoma. These results should be interpreted in light of several limitations of the study, and further studies are needed to confirm the findings of this study.

Research Products

• [Journal Article] Dietary heterocyclic amine intake, NAT2 genetic polymorphism, and colorectal adenoma risk: the colorectal adenoma study in Tokyo. (2015)
  • Author(s): Budhathoki S, Iwasaki M, Yamaji T, Sasazuki S, Takachi R, Sakamoto H, Yoshida T, Tsugane S.
  • Journal Title: Cancer Epidemiol Biomarkers Prev. Volume: 24 Issue: 3 Pages: 613-20
  • DOI: 10.1158/1055-9965.epi-14-1051
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Coffee intake and the risk of colorectal adenoma: the Colorectal Adenoma Study in Tokyo (2015)
  • Author(s): Sanjeev Budhathoki, Motoki Iwasaki, Taiki Yamaji, Shizuka Sasazuki, Shoichiro Tsugane
  • Journal Title: International Journal of Cancer Volume: 印刷中 Issue: 2 Pages: 463-470
  • DOI: 10.1002/ijc.29390
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Coffee intake and the prevalence of colorectal adenoma: the Colorectal Adenoma Study in Tokyo (2015)
  • Author(s): Sanjeev Budhathoki, Motoki Iwasaki, Taiki Yamaji, Shizuka Sasazuki, Shoichiro Tsugane
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2015-10-08 – 2015-10-10
• [Presentation] Dietary heterocyclic amine intake, NAT2 genetic polymorphism and colorectal adenoma risk: the Colorectal Adenoma Study in Tokyo (2014)
  • Author(s): Sanjeev Budhathoki, Motoki Iwasaki, Taiki Yamaji, Shizuka Sasazuki, Ribeka Takachi, Hiromi Sakamoto, Teruhiko Yoshida, Shoichiro Tsugane
  • Organizer: JSPS A3 Foresight Program 2014 Seminar
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2014-06-20 – 2014-06-23
• [Presentation] 血中のインスリン関連マーカーと大腸腺腫との関連にみられた性差 (2012)
  • Author(s): 山地 太樹、岩崎 基、笹月 静、津金 昌一郎
  • Organizer: 日本癌学会
  • Place of Presentation: 北海道
• [Remarks] 大腸腺腫の発生要因を探索する症例対照研究
  • URL: http://epi.ncc.go.jp/mstudy/132/index.html
• [Remarks] 大腸腺腫の発生要因を探索する症例対照研究
  • URL: http://epi.ncc.go.jp/mstudy/132/index.html
• [Remarks] 血中のインスリン関連マーカーと大腸腺腫との関連
  • URL: http://epi.ncc.go.jp/mstudy/491/2777.html