Obesity related parameters and cardiovascular diseases risk factors

• Project/Area Number: 24590837
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: WATANABE MAKOTO 独立行政法人国立循環器病研究センター, 病院, 医長 (40343446)
• Co-Investigator(Renkei-kenkyūsha): MIYAMOTO Yoshihiro 国立循環器病研究センター, 病院, 部長 (10312224) ; KOKUBO Yoshihiro 国立循環器病研究センター, 病院, 医長 (20393217)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: コホート研究 / 地域住民 / 肥満関連指標 / 循環器疾患 / 危険因子 / 糖尿病 / 高血圧 / 繰り返しデータ

Outline of Final Research Achievements

The Suita study, a prospective cohort study of the urban population of Japan, suggested the following three findings. First, waist height ratio (WHtR：WC (cm) divided by height (cm)) was useful for identifying individuals at higher risk for cardiovascular diseases, especially, in the middle-aged men and women. Second, additional increase in waist circumferences (WC) among those with relatively higher WC could lead to the elevated risks of type 2 diabetes.That is, prvention of abdominal obesity is important to reduce the incidence of diabetes. Third, all of following three obesity related parameters, BMI (weight (kg) divided by height (m) squared), WC, WHtR, could predict the incidence of hypertension, and no difference was observed in predictability between BMI and waist related parameters (WC, WHtR).

Research Products

• [Journal Article] Changes in Waist Circumference and the Incidence of Type 2 Diabetes in Community-Dwelling Men and Women: The Suita Study (2015)
  • Author(s): Yukako Tatsumi, Makoto Watanabe, Michikazu Nakai, Yoshihiro Kokubo, Aya Higashiyama, Kunihiro Nishimura, Takashi Kobayashi, Misa Takegami, Yoko M. Nakao, Takuya Watanabe, Akira Okayama, Tomonori Okamura, Yoshihiro Miyamoto
  • Journal Title: Journal of Epidemiology Volume: 25 Issue: 7 Pages: 489-495
  • DOI: 10.2188/jea.JE20140160
  • NAID: 130005086223
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effect of Age on the Association Between Waist-to-Height Ratio and Incidence of Cardiovascular Disease: The Suita Study (2013)
  • Author(s): Tatsumi Y, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, Okamura T, Okayama A, Miyamoto Y
  • Journal Title: Journal of Epidemiology Volume: 23 Issue: 5 Pages: 351-359
  • DOI: 10.2188/jea.JE20130004
  • NAID: 10031194273
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed
• [Presentation] ウエスト周囲長と高尿酸血症発症との関連ー吹田研究ー (2014)
  • Author(s): 中井陸運、渡邊至、東山綾、小久保喜弘、西村邦宏、竹上未紗、中尾葉子、渡邊琢也、岡村智教、宮本恵宏
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎市
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] BMIと内臓脂肪蓄積関連指標の高血圧発症リスクの比較ー吹田研究ー (2014)
  • Author(s): 中井陸運、渡邉至、西村邦宏、小久保喜弘、東山綾、中尾葉子、小林貴、渡邉琢也、岡村智教、宮本恵宏
  • Organizer: 第37回日本高血圧学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] Relationship between BMI and risks of hypertension in an urban Japanese cohort study: the Suita study (2014)
  • Author(s): Nakai M, Watanabe M, Nishimura K, Takegami M, Kokubo Y, Higashiyama A, Okamura T, Miyamoto Y
  • Organizer: American Heart Association (Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions: EPI-NPAM 2014)
  • Place of Presentation: San Francisco
• [Presentation] Which obesity-related indicator is better for predicting incident hypertension? Results from the population-based cohort study of Japan (2014)
  • Author(s): Nakai M, Watanabe M, Nishimura K, Takegami M, Kokubo Y, Higashiyama A, Okamura T, Miyamoto Y
  • Organizer: American Heart Association (Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions: EPI-NPAM 2014)
  • Place of Presentation: San Francisco
• [Presentation] 5-9年間の腹囲の変化と糖尿病発症リスク：吹田研究 (2014)
  • Author(s): 辰巳友佳子 渡邉至 小久保喜弘 西村邦宏 東山綾 岡村智教 岡山明 宮本恵宏
  • Organizer: 第24 回日本疫学会学術総会
  • Place of Presentation: 仙台
• [Presentation] 内臓脂肪蓄積と高血圧発症リスクの検討－吹田研究 (2014)
  • Author(s): 中井陸運 西村邦宏 渡邉至 竹上未紗 小久保喜弘 東山綾 岡村智教 宮本恵宏
  • Organizer: 第24 回日本疫学会学術総会
  • Place of Presentation: 仙台
• [Presentation] The Effect of Age on the Association between Waist-to-height Ratio and the Incidence of Cardiovascular Disease: The Suita Study, Japan
  • Author(s): Yukako Tatsumi, Makoto Watanabe, Yoshihiro Kokubo, Kunihiro Nishimura, Aya Higashiyama, Tomonori Okamura, Akira Okayama, Yoshihiro Miyamoto
  • Organizer: American Heart Association (Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2013 Scientific Sessions)
  • Place of Presentation: New Orleans, USA