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Development of a method for analyzing aristolochic acid in crude drugs and kampo products.

Research Project

Project/Area Number 24590838
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionOsaka Prefectural Institute of Public Health

Principal Investigator

TAKAOMI Tagami  大阪府立公衆衛生研究所, 衛生化学部, 主任研究員 (00321943)

Co-Investigator(Kenkyū-buntansha) TAKEDA Akihiro  大阪府立公衆衛生研究所, 衛生化学部, 技師 (00622755)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords生薬 / アリストロキア酸 / 薬学 / 分析化学
Outline of Final Research Achievements

In the analysis of aristolochic acid in the crude drug using the official method, it is sometimes difficult to judge existence or non-existence of aristolochic acid because of interfering peaks.
In this study, we investigated to develop a sensitive and selective method to analyze aristolochic acid. As a result, a selective method to analyze aristolochic acid in crude drugs and kampo products was established by the combination use of solid-phase extraction and high-performance liquid chromatography/ mass spectrometer.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] A simple and selective detection method for aristolochic acid in crude drugs using solid-phase extraction2013

    • Author(s)
      田上貴臣、武田章弘、淺田安紀子、青山愛倫、土井崇広、川口正美、梶村計志、沢辺善之、尾花裕孝、山崎勝弘
    • Journal Title

      Journal of Natural Medicines

      Volume: 67 Issue: 4 Pages: 838-843

    • DOI

      10.1007/s11418-012-0739-7

    • NAID

      40019788156

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 固相抽出法を用いた生薬・漢方製剤に混入が疑われるアリストロキア酸の簡便・迅速分析

    • Author(s)
      田上貴臣、武田章弘、淺田安紀子、青山愛倫、土井崇広、梶村計志、沢辺善之、山崎勝弘
    • Organizer
      第49回全国衛生化学技術協議会年会
    • Place of Presentation
      香川県
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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