Seroprevalence of HBV and Treponema pallidum in HIV-positive individuals and analysis of HBV genotype
| Project/Area Number |
24590840
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Osaka Prefectural Institute of Public Health |
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Principal Investigator |
KOJIMA Yoko 大阪府立公衆衛生研究所, その他部局等, 研究員 (70291218)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHATA Takuya 大阪府立公衆衛生研究所, ウイルス課, 主任研究員 (80270768)
MORI Haruyo 大阪府立公衆衛生研究所, ウイルス課, 主任研究員 (20250300)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | HIV / HBV / 梅毒トレポネーマ / 感染歴 / HBVジェノタイプ / HBV遺伝子型 / 疫学 / STIs / syphilis |
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| Outline of Final Research Achievements |
This research determined the prevalence of HIV, HBV and Treponema pallidum (TP) in populations who visited primary sexually transmitted infection (STI) clinics in Osaka province. Compared with HIV-negative groups, the HBs antigen-positive rate and the seroprevalence of HBV among HIV positive-individuals were significantly higher (P<0.001). Genetic analysis revealed that 17 of 23 (74%) HBV isolates detected in HIV co-infected cases were the foreign genotypes of Ae and G, including three of Ae/G recombinant viruses. From these results, it is highly recommended for clinicians to consider HIV testing when a patient attending a primary STI clinic is positive for HBs antigen, especially in case it is a foreign genotype HBV. The rate of TP antibody positivity was not significantly different between HIV-positive and HIV-negative groups during 2006-2014.
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Report
(4 results)
Research Products
(10 results)
