| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
Detection and cutting of transmission routes of Mycobacterium tuberculosis is one of the most important public health actions to control the expansion of tuberculosis.Whole-genome sequencing (WGS) gives greater discrimination than widely used genotyping methods, which should improve the ability to trace a transmission of M. tuberculosis.In this study, we focused on one genotype strains (30 strains) to verify the effectiveness of WGS to unvail the transmission routes of the genotype strains. Our WGS analysis idenitified in total 35 single nuclotide variants (SNVs) which subdivided the 30 strains into highly probable transmission chains.This means that current molecular epidemiological study complement with WGS could be a practical approach to get deeper traceability of transmission of M. tuberculosis.
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