Role of tissue heme protein on the toxicokinetics of carbon monoxide.
| Project/Area Number |
24590856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AMENO Kiyoshi 香川大学, 医学部, 准教授 (50019626)
TANAKA Naoko 香川大学, 医学部, 助教 (60700052)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 一酸化炭素 / 中毒 / センサーガスクロマトグラフィー / ヘモグロビン / 飽和度 / 体内動態 / 血液 / 筋肉 / 組織 / 死後拡散 / 毒性 / ミオグロビン |
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| Outline of Final Research Achievements |
We have applied the sensor gas chromatography for the measurement of carboxyhemoglobin (CO-Hb) saturation in blood. It is highly sensitive for carbon monoxide, and it may be applicable for other forensic samples.
No remarkable difference of CO-Hb saturation was observed between heart blood and peripheral venous blood in carbon monoxide related cases. And there was no effect of sample dilution on the value of CO-Hb in case of concentrated blood.
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Report
(4 results)
Research Products
(4 results)
