Application of messenger RNA expression of Chromogranin A to a biological marker for the suicide/non-suicide discrimination
| Project/Area Number |
24590857
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Legal medicine
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | クロモグラニンA / 精神ストレス / RT-PCR / ストレス / 精神的ストレス / 自殺 / メッセンジャーRNA |
|---|
| Outline of Final Research Achievements |
We investigated whether the expression of messenger RNA (mRNA) of the chromogranin A (CgA) protein, which is a high sensitive marker of the psychological stress, improve precision of the suicide/non-suicide discrimination. No significant expression of CgA mRNA in pituitary gland, adrenal gland and submandibular gland of rats (12-38 weeks) after water-immersion restraint were observed. In the autopsy cases (62 cases), expression of CgA mRNA in pituitary gland (p<0.01) and adrenal gland (p<0.05) in suicide victims was significantly higher than in non-suicide victims. Higher expression of CgA mRNA in pituitary gland or adrenal gland in suicide victims may suggest the psychological stress with intentions to commit suicide.
|
Report
(4 results)
Research Products
(1 results)
