| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We investigated whether the expression of messenger RNA (mRNA) of the chromogranin A (CgA) protein, which is a high sensitive marker of the psychological stress, improve precision of the suicide/non-suicide discrimination. No significant expression of CgA mRNA in pituitary gland, adrenal gland and submandibular gland of rats (12-38 weeks) after water-immersion restraint were observed. In the autopsy cases (62 cases), expression of CgA mRNA in pituitary gland (p<0.01) and adrenal gland (p<0.05) in suicide victims was significantly higher than in non-suicide victims. Higher expression of CgA mRNA in pituitary gland or adrenal gland in suicide victims may suggest the psychological stress with intentions to commit suicide.
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