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Application of messenger RNA expression of Chromogranin A to a biological marker for the suicide/non-suicide discrimination

Research Project

Project/Area Number 24590857
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionKochi University

Principal Investigator

NAKANISHI Akinori  高知大学, 教育研究部医療学系, 助教 (10217763)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsクロモグラニンA / 精神ストレス / RT-PCR / ストレス / 精神的ストレス / 自殺 / メッセンジャーRNA
Outline of Final Research Achievements

We investigated whether the expression of messenger RNA (mRNA) of the chromogranin A (CgA) protein, which is a high sensitive marker of the psychological stress, improve precision of the suicide/non-suicide discrimination. No significant expression of CgA mRNA in pituitary gland, adrenal gland and submandibular gland of rats (12-38 weeks) after water-immersion restraint were observed. In the autopsy cases (62 cases), expression of CgA mRNA in pituitary gland (p<0.01) and adrenal gland (p<0.05) in suicide victims was significantly higher than in non-suicide victims. Higher expression of CgA mRNA in pituitary gland or adrenal gland in suicide victims may suggest the psychological stress with intentions to commit suicide.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

Research Products

(1 results)

All 2012

All Presentation (1 results)

  • [Presentation] 顎下腺組織からのクロモグラニンA mRNAの検出2012

    • Author(s)
      中西祥徳、古宮淳一、西村拡起、橋本良明
    • Organizer
      第96次日本法医学会学術全国集会
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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