| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Long treatment of anti-psycotic drug sometimes induces sudden cardiac death, however, forensic pathologists hardly find any findings. We examined the gene expressional profile with microarray analysis for chronic chlorpromazine treatment of mouse. The results showed that arrhythmia and cardiac myopathy might induce. Chlorpromazine treatment resulted in chromatin aggregation in nuclear on mouse heart tissue and cultural cell, and the treatment showed positive signal Tunel method. This strongly suggested that chronic chlorpromazine treatment might induce apoptosis in heart tissue and cell. Additionally, in human heart, the results were the same.
Therefore, chronic chlorpromazine treatment might induce cardiomyopathy and followed sudden cardiac death.
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