Elucidation of intrathrombotic bone-marrow-derived EPC contribute to deep vein thrombosis and its application to thrombus age estimation in mice

• Project/Area Number: 24590863
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: NOSAKA Mizuho 和歌山県立医科大学, 医学部, 助教 (00244731)
• Co-Investigator(Kenkyū-buntansha): ISHIDA Yuko 和歌山県立医科大学, 医学部, 講師 (10364077) ; KIMURA Akihiko 和歌山県立医科大学, 医学部, 准教授 (60136611) ; KONDO Toshikazu 和歌山県立医科大学, 医学部, 教授 (70251923)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 深部静脈血栓塞栓症 / 血管内皮前駆細胞 / サイトカイン / 血栓陳旧度 / MMP / プラスミノーゲン活性因子 / IFN-gamma / TNF-alpha / IL-6 / TNF-Rp55 / 血管新生 / EPC

Outline of Final Research Achievements

Deep vein thrombosis (DVT) is multifactorial and often results from a combination of risk factors such as obesity, pregnancy, aging and malignancy. On the GFP chimeric mice, the GFP-positive cells were detected in their thrombi. This phenomenon was a proof of the myeloid cells migrated from their bone marrow. Eight-week-old male wild type mice were employed in this study. DVT was induced by the ligation of inferior vena cava. At 1, 3, 5, 7, 10, 14 and 21 days, histological and immunohistochemical analyses were performed. In a thrombus age of less than 3 days, CD34+/Flk-2+ EPC were not detected. The intrathrombotic EPC were initially observed in thrombus aged 5 days, and their number increased with advances in thrombus age. Our observations indicate the participation of EPC in the thrombi inducing the accumulation of extracellular matrix components, and therefore, detection of EPC could be a useful marker for thrombus age determination.

Research Products

• [Journal Article] Immunohistochemical detection of intrathrombotic IL-6 and its application to thrombus age estimation (2015)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Hama M, Kawaguchi T, Yamamoto H, Kuninaka Y, Shimada E, Kondo T
  • Journal Title: Int J Legal Med Volume: - Issue: 5 Pages: 1021-1025
  • DOI: 10.1007/s00414-015-1147-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autophagy in skin wounds: a novel marker for vital reactions (2015)
  • Author(s): Kimura A, Ishida Y, Nosaka M, Shiraki M, Hama M, Kawaguchi T, Kuninaka Y, Shimada E, Yamamoto H, Takayasu T, Kondo T.
  • Journal Title: Int J Legal Med Volume: - Issue: 3 Pages: 537-541
  • DOI: 10.1007/s00414-015-1168-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Immunohistochemical analysis on MMP-2 and MMP-9 for wound age determination (2015)
  • Author(s): Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Kawaguchi T, Hama M, Sakamoto S, Shinozaki K, Eisenmenger W, Kondo T.
  • Journal Title: Int J Legal Med Volume: - Issue: 5 Pages: 1043-1048
  • DOI: 10.1007/s00414-015-1167-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Immunohistochemical detection of intrathrombotic macrophage-derived cytokines and its application to thrombus age estimation in murine deep vein thrombosis model (2013)
  • Author(s): Nosaka M，Ishida Y, Kimura A, Kondo T
  • Journal Title: Int J Legal Med Volume: 127(5) Issue: 5 Pages: 937-942
  • DOI: 10.1007/s00414-013-0873-0
  • Peer Reviewed
• [Journal Article] Sudden unexpected neonatal death due to late onset group B streptococcal sepsis―A case report (2013)
  • Author(s): Kawaguchi T, Hama M, Abe M, Suenaga T, Ishida Y, Nosaka M, Kuninaka Y, Kawaguchi M, Yoshikawa N, Kimura A, Kondo T
  • Journal Title: Legal Medicine Volume: 15 Issue: 5 Pages: 260-263
  • DOI: 10.1016/j.legalmed.2013.02.002
  • Peer Reviewed
• [Journal Article] Immunohistochemical detection of uPA, tPA, and PAI-1 in a stasis-induced deep vein thrombosis model and its application to thrombus age estimation (2012)
  • Author(s): Nosaka M, Ishida Y, Kuninaka Y, Kimura A, Kondo T
  • Journal Title: Int J Legal Med Volume: 126 Issue: 3 Pages: 421-425
  • DOI: 10.1007/s00414-012-0680-z
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis on cyclooxygenase-2 for wound age determination (2012)
  • Author(s): Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Takayasu T, Eisenmenger W, Kondo T
  • Journal Title: Int J Legal Med Volume: 126 Issue: 3 Pages: 435-440
  • DOI: 10.1007/s00414-012-0685-7
  • Peer Reviewed
• [Journal Article] Critical role of TNF-α-induced macrophage VEGF and iNOS production in the (2012)
  • Author(s): Lu P
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Issue: 7 Pages: 3516-3526
  • DOI: 10.1167/iovs.10-5548
  • Peer Reviewed
• [Journal Article] A case of myocardial infarction in a young female with subclinical hyperthyroidism (2011)
  • Author(s): Hama M, 他7名
  • Journal Title: Int J Cardiol Volume: 158 Issue: 2 Pages: e23-e25
  • DOI: 10.1016/j.ijcard.2011.10.038
  • Peer Reviewed
• [Presentation] Absence of CCR5 accelerates thrombus formation through reduced VEGF, tPA and uPA expression in mice (2014)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] Luck of IL-6 exaggerates angiotensin II-induced aortic aneurysm and dissection in BALB/c mice (2014)
  • Author(s): Shinozaki K, Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Mukaida N, Kondo t
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] The absence of CCL3/MIP-1alpha exaggerated CaCl2-induced aortic aneurysm (2014)
  • Author(s): Ishida Y, Kuninaka Y, Nosaka M, Tanana T, Shinozaki K, Kimura A, Mukaida N, Kondo T
  • Organizer: 第43回日本免疫学会学術集会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] マウス皮膚創傷治癒におけるオートファジーの役割解析 ―その 1― (2014)
  • Author(s): 石田裕子，田中智大，木村章彦，野坂みずほ，國中由美，川口真理子，近藤稔和
  • Organizer: 第44回日本創傷治癒学会
  • Place of Presentation: ホテルメトロポリタン仙台（仙台市）
  • Year and Date: 2014-12-02 – 2014-12-03
• [Presentation] 死後CT を用いた溺死判定の試み－第一報－ (2014)
  • Author(s): 川口敬士，濵 瑞貴，坂本翔一，西山幸祐，石田裕子，野坂みずほ， 國中由美，川口真理子，木村章彦，近藤稔和
  • Organizer: 第61回日本法医学会学術近畿地方集会
  • Place of Presentation: ノボテル甲子園（兵庫県西宮市）
  • Year and Date: 2014-11-08
• [Presentation] 大動脈解離における IL-6 の病態生理学的役割 (2014)
  • Author(s): 篠﨑浩平，木村章彦，石田裕子，野坂みずほ，坂本翔一，西山幸佑，國中由美，島田 栄美，川口真理子，近藤稔和
  • Organizer: 第61回日本法医学会学術近畿地方集会
  • Place of Presentation: ノボテル甲子園（兵庫県西宮市）
  • Year and Date: 2014-11-08
• [Presentation] Absence of IL-6 accelerates thrombus formation through reduced MMPs and uPA expression in murine deep vein thrombosis model (2014)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: Second Annual Meeting of the International Cytokine and Interon Society (ICIS)
  • Place of Presentation: Melbourne Convention & Exhibition Centre, Melbourne, Australia
  • Year and Date: 2014-10-26 – 2014-10-29
• [Presentation] Forensic pathophysiological study on IL-6 expression for age determination of intrathrombus thrombi (2014)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Kondo T
  • Organizer: 9th International Symposium Advances in Legal Medicine/第98次日本法医学会学術全国集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-16 – 2014-06-20
• [Presentation] Biological clock in skin wounds (2014)
  • Author(s): Kimura A, Ishida Y, Shiraki M, Nosaka M, Kuninaka Y, Kondo T
  • Organizer: 9th International Symposium Advances in Legal Medicine/第98次日本法医学会学術全国集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-16 – 2014-06-20
• [Presentation] Detection of endothelial progenitor cells in human skin wounds and its application for wound age determination (2014)
  • Author(s): Kondo T, Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Eisenmenger W
  • Organizer: 9th International Symposium Advances in Legal Medicine/第98次日本法医学会学術全国集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-16 – 2014-06-20
• [Presentation] Immunohistochemical analysis on cyclooxygenase-2 for wound age determination. (2014)
  • Author(s): Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Takayasu T, Eisenmenger W, Kondo T
  • Organizer: 9th International Symposium Advances in Legal Medicine/第98次日本法医学会学術全国集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-16 – 2014-06-20
• [Presentation] Fatal injury by high pressure water jet init - A case report (2014)
  • Author(s): Iwahashi Y, Inaka S, Shinozaki K, Shiraki M, Shimada E, Kawaguchi M, Ishida Y, Nosaka M, Kuninaka Y, Kimura A, Kondo T
  • Organizer: 9th International Symposium Advances in Legal Medicine/第98次日本法医学会学術全国集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-16 – 2014-06-20
• [Presentation] A case of sudden unexpected death due to sigmoid volvulus (2014)
  • Author(s): Nishiyama K, Sakamoto S, Iwahashi Y, Inaka S, Kawaguchi M, Shimada E, Ishida Y, Nosaka M, Kuninaka Y, Kimura A, Kondo T
  • Organizer: 9th International Symposium Advances in Legal Medicine/第98次日本法医学会学術全国集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-16 – 2014-06-20
• [Presentation] A fatel case of hemoperitoneum after percutaneous radiofrequency ablation in a patient with hepatocellular carcinoma (2014)
  • Author(s): Inaka S, Iwahashi Y, Sakamoto S, Nishiyama K, Kawaguchi M, Shimada E, Ishida Y, Nosaka M, Kuninaka Y, Kimura A, Kondo T
  • Organizer: 9th International Symposium Advances in Legal Medicine/第98次日本法医学会学術全国集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-16 – 2014-06-20
• [Presentation] Lack of IL-6 exaggerates angiotensin II-induced aortic aneurysm and dissection in BALB/c mice (2014)
  • Author(s): Shinozaki K, Kimura A, Shiraki M, Kawagichi M, Shimada E, Ishida Y, Nosaka M, Kuninaka Y, Kondo t
  • Organizer: 9th International Symposium Advances in Legal Medicine/第98次日本法医学会学術全国集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-16 – 2014-06-20
• [Presentation] Determination of acephate and methamidophos in biological specimens by GC-MS in an autopsy case (2014)
  • Author(s): Takayasu T, Ishida Y, Nosaka M, Kawaguchi M, Kuninaka Y, Kimura A, Kondo T
  • Organizer: 9th International Symposium Advances in Legal Medicine/第98次日本法医学会学術全国集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-16 – 2014-06-20
• [Presentation] Foreinsic consideration of methamphetamine-related autopsy cases (2014)
  • Author(s): Sakamoto S, Nishiyama K, Shiraki M, Shinozaki K, Kawaguchi M, Shimada E, Ishida Y, Nosaka M, Kuninaka Y, Kimura A, Takayasu T, Kondo T
  • Organizer: 9th International Symposium Advances in Legal Medicine/第98次日本法医学会学術全国集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-06-16 – 2014-06-20
• [Presentation] Absence of IL-6 accelerates thrombus formation through reduced MMPs and uPA expression in mice (2014)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: Interleukin 6; Biology-Pathophysiology-Therapy
  • Place of Presentation: Atlantic Hotel Kiel, Kiel, Germany
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] Estrogen exaggerates arsenic-induced renal injury through inhibition of IL-6/JAK/STAT3 signaling in female mice (2014)
  • Author(s): Kimura A, Nosaka M, Ishida Y, Mukaida N, Kondo T
  • Organizer: Interleukin 6; Biology-Pathophysiology-Therapy
  • Place of Presentation: Atlantic Hotel Kiel, Kiel, Germany
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] Opposite roles of IFN-γ and TNF-α in resolution of stasis-induced deep vein thrombosis (2014)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Mukaida N, Kondo T
  • Organizer: The 18th International Vascular Biology Meeting Abstracts
  • Place of Presentation: みやこめっせ・京都市勧業館（京都市）
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] Lack of IFN-γ exaggerates ANG II-induced aortic aneurysm (2014)
  • Author(s): Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: The 18th International Vascular Biology Meeting Abstracts
  • Place of Presentation: みやこめっせ・京都市勧業館（京都市）
  • Year and Date: 2014-04-14 – 2014-04-17
• [Presentation] 深部静脈血栓症モデルにおけるTNF-Rp55の病態生理学的役割解析 (2012)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，國中由美，川口真理子，近藤稔和
  • Organizer: 第96次日本法医学会学術全国集会
  • Place of Presentation: アクトシティ浜松
• [Presentation] A role of IFN-γin the pathogenesis of pressure overload-induced heart failure (2012)
  • Author(s): 木村章彦，石田裕子，野坂みずほ，川口真理子，國中由美，近藤稔和
  • Organizer: 第96次日本法医学会学術全国集会
  • Place of Presentation: アクトシティ浜松
• [Presentation] エチゾラムが検出された８事例 (2012)
  • Author(s): 高安達典，石田裕子，野坂みずほ，川口真理子，國中由美，木村章彦，近藤稔和
  • Organizer: 第96次日本法医学会学術全国集会
  • Place of Presentation: アクトシティ浜松
• [Presentation] Pivotal role of the CCL5-CCR5 axis for recruitment of endothelial progenitor cells in wound healing (2012)
  • Author(s): 石田裕子，木村章彦，野坂みずほ，國中由美，川口真理子，近藤稔和
  • Organizer: 第96次日本法医学会学術全国集会
  • Place of Presentation: アクトシティ浜松
• [Presentation] Absence of TNF-Rp55 delays thrombus resolution through reduced expression of MMPs and uPA (2012)
  • Author(s): Ishida Y, Nosaka M, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: The 20th International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: 東京大学 山上会館
• [Presentation] The lack of TNF-Rp55 delays thrombosis resolution through reduced expression of MMPs and uPA (2012)
  • Author(s): 石田裕子，野坂みずほ，木村章彦，國中由美，向田直史，近藤稔和
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡
• [Presentation] 圧負荷による代償性心肥大におけるIFN-γの役割 (2012)
  • Author(s): 木村章彦，石田裕子，野坂みずほ，向田直史，近藤稔和
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡
• [Presentation] Forensic pathology of Forensic pathological study on dynamics of intrathrombus IFN-γ for age determination of intravenous thrombi (2012)
  • Author(s): Nosaka M, Ishida Y, Kuninaka Y, Kawaguchi M, Kimura A, Kondo T
  • Organizer: 22nd Congress of the International Academy of Legal Medicine
  • Place of Presentation: Halic Congress Center, Istanbul, Turkey
• [Presentation] Pathophysiological role of TNF-Rp55 on murine deep vein thrombosis model (2012)
  • Author(s): Nosaka M, Ishida Y, Kuninaka Y, Kawaguchi M, Kimura A, Kondo T
  • Organizer: 22nd Congress of the International Academy of Legal Medicine
  • Place of Presentation: Halic Congress Center, Istanbul, Turkey
• [Presentation] Effect of wound on circadian rhythm of skin tissue (2012)
  • Author(s): Kimura A, Nosaka M, Ishida Y, Kuninaka Y, Kondo T
  • Organizer: 22nd Congress of the International Academy of Legal Medicine
  • Place of Presentation: Halic Congress Center, Istanbul, Turkey
• [Presentation] IFN-γ plays a protective role in pressure overload-induced cardiac hypertrophy through PI3K/Akt signaling activation (2012)
  • Author(s): Kimura A, Ishida Y, Nosaka M, Mukaida N, Kondo T
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場，神戸国際展示場
• [Presentation] Lack of TNF-Rp55 delays thrombus resolution through reduced MMPs and uPA expression in mice (2012)
  • Author(s): Nosaka M，Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場，神戸国際展示場
• [Presentation] Essential roles of CCL3-CCR1 axis in the pathogenesis of antigen-induced arthritis (2012)
  • Author(s): Ishida Y, Inui M, Kimura A, Nosaka M, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第41回日本免疫学会学術集
  • Place of Presentation: 神戸国際会議場，神戸国際展示場
• [Presentation] Essential roles of CCL3-CCR1 axis in the pathogenesis of antigen-induced arthritis
  • Author(s): Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Kawaguchi M, Mukaida N, Kondo T
  • Organizer: The Joint international Meeting of The 78th Meeting of the Japanese Society of Interferon and Cytokine Research and The 21st International Symposium on Molecular Cell Biology of Macrophages 2013
  • Place of Presentation: Toshi Center Hotel Tokyo
• [Presentation] IFN-γ/Stat5 axis is essential in compensatory cardiac hypertrophy induced by pressure overload
  • Author(s): Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Kawaguchi M, Mukaida N, Kondo T
  • Organizer: The Joint international Meeting of The 78th Meeting of the Japanese Society of Interferon and Cytokine Research and The 21st International Symposium on Molecular Cell Biology of Macrophages 2013
  • Place of Presentation: Toshi Center Hotel Tokyo
• [Presentation] 深部静脈血栓塞栓症モデルにおける血栓の病態生理学的変化とその血栓陳旧度判定への応用（第３報）
  • Author(s): 野坂みずほ，石田裕子，木村章彦，近藤稔和
  • Organizer: 第97次日本法医学会学術全国集会
  • Place of Presentation: ロイトン札幌
• [Presentation] 皮膚損傷における血管内皮前駆細胞の検出と受傷後経過時間判定への応用
  • Author(s): 石田裕子，木村章彦，野坂みずほ，國中由美，川口真理子，Wolfgang Eisenmenger，近藤稔和
  • Organizer: 第97次日本法医学会学術全国集会
  • Place of Presentation: ロイトン札幌
• [Presentation] 損傷が体内時計に及ぼす影響―皮膚損傷について―
  • Author(s): 木村章彦，石田裕子，野坂みずほ，國中由美，川口真理子，近藤稔和
  • Organizer: 第97次日本法医学会学術全国集会
  • Place of Presentation: ロイトン札幌
• [Presentation] 圧負荷による代償性心肥大の分子メカニズム―IFN-γの役割について
  • Author(s): 木村章彦，石田裕子，野坂みずほ，向田直史，近藤稔和
  • Organizer: 第34回日本炎症・再生医学会
  • Place of Presentation: 国立京都国際会館
• [Presentation] Lack of TNF-Rp55 delays thrombus resolution in a stasis-induced DVT model through reduced MMPs and uPA expression
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milano Congressi, Milan, Italy
• [Presentation] Pathophysiological roles of the CX3CL1-CX3CR1 axis in chemical-induced skin carcinogenesis
  • Author(s): Ishida Y, Nosaka M, Kimura A, Kuninaka Y, Kawaguchi M, Mukaida N, Kondo T
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milano Congressi, Milan, Italy
• [Presentation] Essential involvement of tumor-derived IDO in ovarian cancer progresssion
  • Author(s): Tanizaki Y, Kobayashi A, Yahata T, Yamamoto M, Shiro M, Mabuchi Y, Minami S, Nosaka M, Kondo T, Ino K
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: Milano Congressi, Milan, Italy
• [Presentation] 皮膚組織におけるautophagyのcircadian rhythmと創傷治癒
  • Author(s): 近藤稔和，木村章彦，石田裕子，野坂みずほ，國中由美，川口真理子
  • Organizer: 第43回日本創傷治癒学会
  • Place of Presentation: 別府湾ロイヤルホテル
• [Presentation] 肝臓癌に対するラジオ波焼灼術後に生じた出血性ショックの１剖検例
  • Author(s): 井中将吾，深海三恵，川口敬士，濵 瑞貴，石田裕子，野坂みずほ，國中由美，川口真理子，木村章彦，近藤稔和
  • Organizer: 第60回日本法医学会学術近畿地方集会
  • Place of Presentation: 近畿大学医学部 大講堂
• [Presentation] シデムシの蚕食による急速な白骨化の１事例
  • Author(s): 深海三恵，井中将吾，川口敬士，濵 瑞貴，石田裕子，野坂みずほ，國中由美，川口真理子，木村章彦，近藤稔和
  • Organizer: 第60回日本法医学会学術近畿地方集会
  • Place of Presentation: 近畿大学医学部 大講堂
• [Presentation] Absence of IL-6 accelerates thrombus formation through reduced MMPs and uPA expression in mice
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Lack of IFN-gamma exergarates ANG II-induced aortic aneurysm through reduction of autophagy
  • Author(s): Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Pathophysiological roles of the CX3CL1-CX3CR1 axis in chemical-induced skin carcinogenesis
  • Author(s): Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] 肺線維症におけるCX3Cケモカインの役割解析
  • Author(s): 石田裕子，木村章彦，野坂みずほ，國中由美，向田直史，近藤稔和
  • Organizer: 第13回分子予防環境医学研究会
  • Place of Presentation: 和歌山県民文化会館
• [Presentation] マウス急性砒素腎障害モデルにおけるIL-6およびエストロゲンの役割解析
  • Author(s): 木村章彦，石田裕子，野坂みずほ，國中由美，向田直史，近藤稔和
  • Organizer: 第13回分子予防環境医学研究会
  • Place of Presentation: 和歌山県民文化会館
• [Presentation] 巨大卵巣嚢腫の１剖検例
  • Author(s): 鈴木正暉，川口敬士，石田裕子，野坂みずほ，國中由美，川口真理子，木村章彦，近藤稔和
  • Organizer: 第59回日本法医学会学術近畿地方集会
  • Place of Presentation: 京都府立医科大学附属図書館ホール