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Study on the threshold for brain damage due to carbon monoxide poisoning

Research Project

Project/Area Number 24590866
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionTokyo Medical University

Principal Investigator

HARA SHUICHI  東京医科大学, 医学部, 准教授 (70208651)

Co-Investigator(Renkei-kenkyūsha) KURIIWA Fumi  東京医科大学, 医学部, 助手 (30468665)
Research Collaborator KOBAYASHI Masamune  東京医科大学, 医学部, 助教
MIZUKAMI Hajime  東京医科大学, 医学部, 准教授
MUKAI Toshiji  聖マリアンナ医科大学, 医学部, 教授
IKEMATSU Kazuya  長崎大学, 医学部, 教授
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords一酸化炭素中毒 / ヒドロキシルラジカル / NADPH oxidase / dual oxidase 2 / mRNA / ラット / 線条体 / Dual oxidase / siRNA
Outline of Final Research Achievements

We found that severe, but not non-severe, carbon monoxide (CO) poisoning enhanced mRNA expression of dual oxidase 2, which is a member of NADPH oxidase family involved in oxidative stress, in rat striatum. No such enhancement of mRNA expression was observed for other members of NADPH oxidase family. Inhibition of NADPH oxidase, but not xanthine oxidase, suppressed production of active oxygen species induced not only by severe CO poisoning, but also by enhancement of intracellular cAMP production due to forskolin. These findings suggest that NADPH oxidase may be under the control of cAMP signaling and contribute to brain damage due to severe CO poisoning. It is likely that dual oxidase 2 plays a role on brain damage. It is necessary to further examine the role of dual oxidase 2.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Different mechanisms of hydroxyl radical production susceptible to purine P2 receptor antagonists between carbon monoxide poisoning and exogenous ATP in rat striatum2014

    • Author(s)
      Hara S, Kobayashi M, Kuriiwa F, Mukai T, Mizukami H.
    • Journal Title

      Free Radical Research

      Volume: 48 Issue: 11 Pages: 1322-1333

    • DOI

      10.3109/10715762.2014.951842

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 急性一酸化炭素中毒時のヒドロキシルラジカル生成におけるNADPH oxidaseの関与2015

    • Author(s)
      原 修一、小林正宗、栗岩ふみ、池松和哉、向井敏二、水上 創
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザ かるぽーと
    • Year and Date
      2015-06-11
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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