| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Existing methods for the detection of the drugs in biological samples usually involve time-consuming multi-step pretreatment. To avoid such sample pretreatments, special HPLC columns, which enabled direct injection of crude biological samples, were developed; we applied them to compounds of forensic toxicological interest. In this study, we have established an automated on-line method for ultra-fast determination of haloperidol and its metabolites, which is widely used as an antipsychotic drug and frequently encountered in the fields of forensic and clinical toxicology, in biological samples, by HPLC-MS/MS with backflush column-switching using one of special HPLC columns and a monolithic separation column.
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