Neuroimmunological basis on response to stress in patients with irritable bowel syndrome

• Project/Area Number: 24590875
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: Kanazawa Motoyori 東北大学, 医学(系)研究科(研究院), 准教授 (70323003)
• Co-Investigator(Kenkyū-buntansha): KANO Michiko 東北大学, 学際科学フロンティア研究所, 助教 (20344658) ; FUKUDO Shin 東北大学, 大学院医学系研究科, 教授 (80199249)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 過敏性腸症候群 / 消化管運動 / 内臓知覚 / コルチコトロピン放出ホルモン / ストレス / 養育環境

Outline of Final Research Achievements

We tested the hypotheses that patients with irritable bowel syndrome (IBS) show exaggeration of phasic and tonic motility responses in the colorectum using a barostat device after exogenous corticotropin-releasing hormone (CRH).
After administration of CRH, IBS patients showed more increased smooth muscle tone and more phasic contractions compared to healthy subjects. Pain thresholds to colorectal distention were associated with exaggeration of gastrointestinal motility responses but the response to serum levels of ACTH or cortisol and parental behaviors in chilhood were not.
These findings support the idea that more increased peripheral CRH signaling pathway may induce exacerbation of IBS symptoms as well as abnormal central CRH system. Development of novel treatment options focused on CRH and/or its receptors should be warranted for management of IBS.

Research Products

• [Journal Article] Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome. (2016)
  • Author(s): Komuro H, Sato N, Sasaki A, Suzuki N, Kano M, Tanaka Y, Yamaguchi-Kabata Y, Kanazawa M, Warita H, Aoki M, Fukudo S.
  • Journal Title: PLoS One Volume: 11 Issue: 1 Pages: e0147817-e0147817
  • DOI: 10.1371/journal.pone.0147817
  • Peer Reviewed / Open Access
• [Journal Article] Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome. (2016)
  • Author(s): Sasaki A, Sato N, Suzuki N, Kano M, Tanaka Y, Kanazawa M, Aoki M, Fukudo S.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0149322-e0149322
  • DOI: 10.1371/journal.pone.0149322
  • Peer Reviewed / Open Access
• [Journal Article] Validity and reliability of the Japanese version of the Rome III diagnostic questionnaire for irritable bowel syndrome and functional dyspepsia. (2015)
  • Author(s): Kanazawa M, Nakajima S, Oshima T, Whitehead WE, Sperber AD, Palsson OS, Drossman DA, Miwa H, Fukudo S.
  • Journal Title: J Neurogastroenterol Motil Volume: 21 (4) Issue: 4 Pages: 537-544
  • DOI: 10.5056/jnm15016
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effect of 5-hydroxytryptamine receptor 4 agonist mosapride on human gastric accommodation. (2015)
  • Author(s): Amano T, Ariga H, Kurematsu A, Yamato S, Morioka S, Masaka A, Kanazawa M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil Volume: 27 Issue: 9 Pages: 1303-1309
  • DOI: 10.1111/nmo.12623
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluation of Kampo medicine in the clinical practice guideline for irritable bowel syndrome. (2015)
  • Author(s): Fukudo S, Kaneko H, Akiho H, Inamori M, Endo Y, Okumura T, Kanazawa M, Kamiya T, Sato K, Chiba T, Furuta K, Yamato S, Arakawa T, Fujiyama Y, Azuma T, Fujimoto K, Mine T, Miura S, Kinoshita Y, Watanabe M, Sugano K, Shimosegawa T.
  • Journal Title: J Gastroenterol Volume: 50 Issue: 7 Pages: 817-818
  • DOI: 10.1007/s00535-015-1074-z
  • Peer Reviewed
• [Journal Article] Serotonin Transporter Gene Polymorphism Modulates Activity and Connectivity within an Emotional Arousal Network of Healthy Men during an Aversive Visceral Stimulus. (2015)
  • Author(s): Kilpatrick LA, Mayer EA, Labus JS, Gupta A, Hamaguchi T, Mizuno T, Komuro H, Kano M, Kanazawa M, Aoki M, Fukudo S.
  • Journal Title: PLoS One Volume: 10 Issue: 4 Pages: 1-15
  • DOI: 10.1371/journal.pone.0123183
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 過敏性腸症候群に対する新しい食事療法－低FODMAPダイエットを中心として－． (2015)
  • Author(s): 金澤素, 福土審.
  • Journal Title: 分子消化器病 Volume: 12 Pages: 152-158
• [Journal Article] One Point Advice: エビデンス・ベイスト・メディスンとナラティブ・ベイスト・メディスン． (2015)
  • Author(s): 金澤素．
  • Journal Title: Medical Practice Volume: 32 Pages: 1225-1225
• [Journal Article] 機能性消化管障害とタイトジャンクション. (2015)
  • Author(s): 金澤素，福土審．
  • Journal Title: G.I.Research Volume: 23 Pages: 514-519
• [Journal Article] Injection of corticotropin-releasing hormone into the amygdala aggravates visceral nociception and induces noradrenaline release in rats. (2015)
  • Author(s): Su J, Tanaka Y, Muratsubaki T, Kano M, Kanazawa M, Fukudo S.
  • Journal Title: Neurogastroenterol Motil Volume: 27 Issue: 1 Pages: 30-39
  • DOI: 10.1111/nmo.12462
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Evidence-based clinical practice guidelines for irritable bowel syndrome. (2015)
  • Author(s): Fukudo S, Kaneko H, Akiho H, Inamori M, Endo Y, Okumura T, Kanazawa M, Kamiya T, Sato K, Chiba T, Furuta K, Yamato S, Arakawa T, Fujiyama Y, Azuma T, Fujimoto K, Mine T, Miura S, Kinoshita Y, Sugano K, Shimosegawa T.
  • Journal Title: J Gastroenterol Volume: 50 Issue: 1 Pages: 11-30
  • DOI: 10.1007/s00535-014-1017-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 過敏性腸症候群のEBMとNBM. (2015)
  • Author(s): 金澤素, 福土審．
  • Journal Title: 心身医 Volume: 55 Pages: 14-18
  • Peer Reviewed
• [Journal Article] Update -過敏性腸症候群の心身医学的治療-. (2015)
  • Author(s): 金澤素, 福土審．
  • Journal Title: 心身医 Volume: 55 Pages: 218-223
  • Peer Reviewed
• [Journal Article] 機能性消化管疾患と中枢性調節機序－脳機能イメージングからみた腸管運動および感受性の変化． (2015)
  • Author(s): 金澤素、鹿野理子、福土審．
  • Journal Title: 臨牀消化器内科 Volume: 30 Pages: 201-209
• [Journal Article] 脳腸相関を画像化する：PET. (2015)
  • Author(s): 福土審，金澤素，鹿野理子，森下城，村椿智彦，田中由佳里，田代学，谷内一彦．
  • Journal Title: G.I.Research Volume: 23 Pages: 120-123
• [Journal Article] Motility response to colonic distention is increased in post-infectious irritable bowel syndrome (PI-IBS). (2014)
  • Author(s): Kanazawa M, Palsson OS, Van Tilburg MAL, Gangarosa LM, Fukudo S, Whitehead WE.
  • Journal Title: Neurogastroenterol Motil Volume: 26 Issue: 5 Pages: 696-704
  • DOI: 10.1111/nmo.12318
  • Peer Reviewed
• [Journal Article] 過敏性腸症候群の病態と治療． (2014)
  • Author(s): 金澤素，福土審．
  • Journal Title: Medical Practice Volume: 31 Pages: 1214-1223
• [Journal Article] 腸内細菌は過敏性腸症候群（IBS）とどのようにかかわっているか． (2014)
  • Author(s): 金澤素, 福土審．
  • Journal Title: 分子消化器病 Volume: 11 Pages: 221-226
• [Journal Article] 過敏性腸症候群とCRH (corticotropin-releasing hormone). (2014)
  • Author(s): 金澤素, 福土審．
  • Journal Title: 消化器内科 Volume: 59 Pages: 201-206
• [Journal Article] IBS治療の考え方・治療戦略のポイント. (2014)
  • Author(s): 金澤素, 福土審．
  • Journal Title: 消化器の臨床 Volume: 17 Pages: 431-435
• [Journal Article] 過敏性腸症候群における局所脳活動と神経内分泌反応． (2014)
  • Author(s): 鹿野理子，金澤素，福土審．
  • Journal Title: 消化器内科 Volume: 58 Pages: 122-127
• [Journal Article] ストレスによる心窩部痛症状および消化管機能反応に対する六君子湯の効果． (2014)
  • Author(s): 庄司知隆、白取美幸、遠藤由香、金澤素、本郷道夫、福土審．
  • Journal Title: 日本東洋心身医学研究 Volume: 29 Pages: 21-25
• [Journal Article] Gastrointestinal specific anxiety in irritable bowel syndrome: validation of the Japanese version of the visceral sensitivity index for university students (2014)
  • Author(s): Saigo T, Tayama J, Hamaguchi T, Nakaya N, Tomiie T, Bernick PJ, Kanazawa M, Labus JS, Naliboff BD, Shirabe S, Fukudo S.
  • Journal Title: Biopsychosocial Medicine Volume: 8 Issue: 1 Pages: 1-9
  • DOI: 10.1186/1751-0759-8-10
  • NAID: 120006986597
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between infectious gastroenteritis and irritable bowel syndrome. (2014)
  • Author(s): Kanazawa M, Fukudo S.
  • Journal Title: Clin J Gastroenterol Volume: 7 Issue: 1 Pages: 14-18
  • DOI: 10.1007/s12328-013-0444-4
  • Peer Reviewed
• [Journal Article] Preceding stimulation affects brain activation in response to colonic distention in humans. (2013)
  • Author(s): Hamaguchi T, Kano M, Kanazawa M, Itoh M, Yanai K, Fukudo S.
  • Journal Title: Psychosom Med Volume: 75 Issue: 5 Pages: 453-462
  • DOI: 10.1097/psy.0b013e3182926682
  • Peer Reviewed
• [Journal Article] A randomized controlled trial of lifestyle self-monitoring for irritable bowel syndrome in female nursing school students. (2013)
  • Author(s): Okami Y et al.
  • Journal Title: Open Journal of Gastroenterology Volume: 3(8) Issue: 08 Pages: 328-336
  • DOI: 10.4236/ojgas.2013.38058
  • Peer Reviewed
• [Journal Article] Irritable bowel syndrome in Chinese nursing and medical school students – Related lifestyle and psychological factors. (2013)
  • Author(s): Okami Y et al.
  • Journal Title: Open Journal of Gastroenterology Volume: 3(1) Issue: 01 Pages: 55-63
  • DOI: 10.4236/ojgas.2013.31009
  • Peer Reviewed
• [Journal Article] Post-infectious IBSの概念とリスク因子を考える． (2013)
  • Author(s): 金澤素，福土審．
  • Journal Title: 分子消化器病 Volume: 10 Pages: 236-241
• [Journal Article] 中枢神経の変化－機能性消化管障害における脳腸相関の脳機能イメージング. (2013)
  • Author(s): 金澤素，福土審.
  • Journal Title: 日内会誌 Volume: 102 Pages: 17-24
  • NAID: 10031170558
  • Peer Reviewed
• [Journal Article] 期待される新薬の効果と使い方－ルビプロストン. (2013)
  • Author(s): 金澤素，福土審.
  • Journal Title: 消化器の臨床 Volume: 16 Pages: 58-62
• [Journal Article] Serotonin transporter gene promoter polymorphism and alexithymia (2012)
  • Author(s): Kano M, Kanazawa M, et al
  • Journal Title: Neuropsychobiology Volume: 65 Issue: 2 Pages: 76-82
  • DOI: 10.1159/000329554
  • Peer Reviewed
• [Journal Article] Enhanced auditorybrainstem response and parental bonding style in children with gastrointestinal symptoms (2012)
  • Author(s): Seino S, Watanabe S, Ito N, Sasaki K, Shoji K, Miura S, Kozawa K, Nakai K, Sato H, Kanazawa M, Fukudo S
  • Journal Title: PLoS One Volume: 7(3) Issue: 3 Pages: e32913-e32913
  • DOI: 10.1371/journal.pone.0032913
  • Peer Reviewed
• [Journal Article] Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome (2012)
  • Author(s): Sato N, Suzuki N, Sasaki A, Aizawa E, Obayashi T, Kanazawa M, Mizuno T, Kano M, Aoki M, Fukudo S
  • Journal Title: PLoS One Volume: 7(9) Issue: 9 Pages: e42450-e42450
  • DOI: 10.1371/journal.pone.0042450
  • Peer Reviewed
• [Journal Article] Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling (2012)
  • Author(s): Aizawa E, Sato Y, Kochiyama T, Saito N, Izumiyama M, Morishita J, Kanazawa M, Shima K, Mushiake H, Hongo M, Fukudo S
  • Journal Title: Gastroenterology Volume: 143(5) Issue: 5 Pages: 1188-1198
  • DOI: 10.1053/j.gastro.2012.07.104
  • Peer Reviewed
• [Journal Article] 過敏性腸症候群の治療アウトカム評価. (2012)
  • Author(s): 金澤素, 篠崎雅江, 遠藤由香, 庄司知隆, 本郷道夫, 福土審.
  • Journal Title: 消心身医 Volume: 19 Pages: 21-25
  • Peer Reviewed
• [Journal Article] 大震災のストレスと心身医学：仙台・宮城からの速報. (2012)
  • Author(s): 福士審, 庄司知隆, 遠藤由香, 鹿野理子, 田村太作, 森下城, 佐藤康弘, 町田貴胤, 町田知美, 野田智子, 橋田かなえ, 田中由佳里, 金澤素.
  • Journal Title: 心身医 Volume: 52 Pages: 388-395
  • Peer Reviewed
• [Journal Article] 機能性胃腸症の病態と治療. (2012)
  • Author(s): 本郷道夫，福土審，庄司知隆，遠藤由香，金澤素，佐藤康弘，田村太作.
  • Journal Title: 日内会誌 Volume: 101 Pages: 2690-2697
  • NAID: 10031130664
  • Peer Reviewed
• [Journal Article] Functional dyspepsiaの視覚ストレスによる胃機能の変調. (2012)
  • Author(s): 庄司知隆, 白取美幸, 森下城, 遠藤由香, 町田貴胤, 町田知美, 金澤素, 本郷道夫, 福土審.
  • Journal Title: 消心身医 Volume: 19 Pages: 26-30
  • Peer Reviewed
• [Journal Article] 東日本大震災における心療内科医の役割 東日本大震災の被災地心療内科患者への影響. (2012)
  • Author(s): 庄司知隆, 遠藤由香, 町田知美, 町田貴胤, 田村太作, 佐藤康弘, 橋田かなえ, 野田智子, 田中由佳里, 鹿野理子, 金澤素, 本郷道夫, 福士審.
  • Journal Title: 日本心療内科学会誌 Volume: 16 Pages: 248-254
  • Peer Reviewed
• [Presentation] 過敏性腸症候群の腸内細菌叢の解析. (2015)
  • Author(s): 金澤素, 宮本健太郎, 岡健太郎, 高橋志達, 鹿野理子, 福土審.
  • Organizer: 第17回日本神経消化器病学会
  • Place of Presentation: 恩納, 沖縄科学技術大学院大学
  • Year and Date: 2015-11-12
  • Invited
• [Presentation] ストレスによる上腹部症状に対する六君子湯の効果. (2015)
  • Author(s): 庄司知隆, 白取美幸, 遠藤由香, 金澤素, 本郷道夫, 福土審.
  • Organizer: 第17回日本神経消化器病学会
  • Place of Presentation: 恩納, 沖縄科学技術大学院大学
  • Year and Date: 2015-11-12
  • Invited
• [Presentation] ラットにおける副腎皮質刺激ホルモン放出因子の扁桃体内投与による内臓痛覚の増強. (2015)
  • Author(s): 蘇晶, 田中由佳里, 村椿智彦, 金澤素, 福土審.
  • Organizer: 第22回日本行動医学会学術総会
  • Place of Presentation: 仙台, 艮陵会館
  • Year and Date: 2015-10-16
• [Presentation] コルチコトロピン放出ホルモン受容体2遺伝子における一塩基多型, ハプロタイプと過敏性腸症候群との関連. (2015)
  • Author(s): 小室葉月, 佐藤菜保子, 佐々木彩加, 鈴木直輝, 鹿野理子, 田中由佳里, 山口（加畑）由美, 金澤素, 割田仁, 青木正志, 福土審.
  • Organizer: 第22回日本行動医学会学術総会
  • Place of Presentation: 仙台, 艮陵会館
  • Year and Date: 2015-10-16
• [Presentation] 食欲制御へのマインドフルネスの効果 -脳機能イメージングから-. (2015)
  • Author(s): 村椿智彦, 鹿野理子, 金澤素, 福土審.
  • Organizer: 第22回日本行動医学会学術総会
  • Place of Presentation: 仙台, 艮陵会館
  • Year and Date: 2015-10-16
  • Invited
• [Presentation] 過敏性腸症候群の新たな治療法 ‐反復経頭蓋磁気刺激の可能性‐. (2015)
  • Author(s): 相澤祐一, 森下城, 鹿野理子, 金澤素, 筒井健一郎, 福土審.
  • Organizer: 第22回日本行動医学会学術総会
  • Place of Presentation: 仙台, 艮陵会館
  • Year and Date: 2015-10-16
  • Invited
• [Presentation] 過敏性腸症候群（IBS）における副腎皮質刺激ホルモン（ACTH）反応性の内臓感覚脳活動への影響. (2015)
  • Author(s): 鹿野理子, 村椿智彦, 八木橋真央, 森下城, Ly HG, Dupont P, Van Oudenhove L, 金澤素, 福土審.
  • Organizer: 第22回日本行動医学会学術総会
  • Place of Presentation: 仙台, 艮陵会館
  • Year and Date: 2015-10-16
  • Invited
• [Presentation] Smoking and post-infectious etiology in prevalence of irritable bowel syndrome. (2015)
  • Author(s): Fukudo S, Muratsubaki T, Kano M, Endo Y, Shoji T, Sato Y, Kanazawa M.
  • Organizer: The 23rd World Congress of Psychosomatic Medicine (ICPM 2015)
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2015-08-19
  • Int'l Joint Research
• [Presentation] The Association between alexithymia and hypothalamic-pituitary-adrenal axis reaction in irritable bowel syndrome. (2015)
  • Author(s): Yagihashi M, Kano M, Muratsubaki T, Morishita J, Tanaka Y, Kanazawa M, Fukudo S.
  • Organizer: The 23rd World Congress of Psychosomatic Medicine (ICPM 2015)
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2015-08-19
  • Int'l Joint Research
• [Presentation] Brain actitivity during rectal distension associated with increased colonic response to CRH in IBS subjects. (2015)
  • Author(s): Kano M, Muratsubaki T, Yagihashi M, Morishita J, Tanaka Y, Ly HG, Dupont P, Van Oudenhove L, Kanazawa M, Fukudo S.
  • Organizer: The 38th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kobe, Kobe International Conference Center/Kobe International Exhibition Hall
  • Year and Date: 2015-07-28
  • Int'l Joint Research
• [Presentation] 過敏性腸症候群におけるHPA軸反応性とAlexithymia尺度の関連. (2015)
  • Author(s): 八木橋真央, 鹿野理子, 金澤素, 村椿智彦, 田中由佳里, 福土審.
  • Organizer: 第56回日本心身医学会総会
  • Place of Presentation: 東京, タワーホール船堀
  • Year and Date: 2015-06-26
• [Presentation] 過敏性腸症候群に対するグルココルチコイド受容体遺伝子多型の影響について. (2015)
  • Author(s): 佐々木彩加, 小室葉月, 佐藤菜保子, 金澤素, 青木正志, 福土審.
  • Organizer: 第56回日本心身医学会総会
  • Place of Presentation: 東京, タワーホール船堀
  • Year and Date: 2015-06-26
• [Presentation] 過敏性腸症候群のambiguityな状況下における意思決定時の脳内基盤. (2015)
  • Author(s): 相澤恵美子, 佐藤康弘, 森下城,関口敦, 鹿野理子, 金澤素, 福土審.
  • Organizer: 第56回日本心身医学会総会
  • Place of Presentation: 東京, タワーホール船堀
  • Year and Date: 2015-06-26
• [Presentation] Decreased concentration of whole blood serotonin in IBS with diarrhea. (2015)
  • Author(s): Kanazawa M, Palsson OS, van Tilburg MA, Gangarosa LM, Fukudo S, Whitehead WE.
  • Organizer: The 116th Annual Meeting of American Gastroenterological Association (DDW 2015)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Cytokine activation is associated with psychological distress, motility and visceral hypersensitivity in irritable bowel syndrome (IBS). (2015)
  • Author(s): van Tilburg MA, Palsson OS, Kanazawa M, Barrow DA, Whitehead WE.
  • Organizer: The 116th Annual Meeting of American Gastroenterological Association (DDW 2015)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Identifying functionally meaningful biomarkers in irritable bowel syndrome. (2015)
  • Author(s): Sugai C, Tanaka Y, Kanazawa M, Morishita J, Kano M, Shoji T, Endo Y, Fukudo S.
  • Organizer: The 116th Annual Meeting of American Gastroenterological Association (DDW 2015)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Altered relation of autonomic response and pituitary-adrenal response during colorectal distention with corticotropin-releasing hormone in irritable bowel syndrome. (2015)
  • Author(s): Tanaka Y, Morishita J, Kanazawa M, Tashiro M, Fukudo S.
  • Organizer: The 116th Annual Meeting of American Gastroenterological Association (DDW 2015)
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Corticotropin-releasing hormone-induced changes in colonic tone in patients with irritable bowel syndrome. (2014)
  • Author(s): Kanazawa M, Kano M, Fukudo S.
  • Organizer: JDDW2014 （第56回日本消化器病学会大会）
  • Place of Presentation: 神戸（神戸ポートピアホテル）
  • Year and Date: 2014-10-23 – 2014-10-26
  • Invited
• [Presentation] Motility response and visceral pain sensitivity to colonic distention in post-infectious irritable bowel syndrome (PI-IBS). (2014)
  • Author(s): Kanazawa M, Palsson OS, Van Tilburg MAL, Gangarosa LM, Fukudo S, Whitehead WE.
  • Organizer: The 5th Asian Pacific Topic Conference (APTC2014)
  • Place of Presentation: Kobe, Japan (Kobe International Conferance Center)
  • Year and Date: 2014-10-22
  • Invited
• [Presentation] Role of dopamine in hypnotic analgesia under visceral stimulation. (2014)
  • Author(s): Fukudo S, Morrishita J, Watanabe S, Kawahata K, Ishizu N, Tanaka Y, Watanuki S, Hiraoka K, Kano M, Kanazawa M, Yanai K, Tashiro M.
  • Organizer: 13th International Congress of Behavioral Medicine
  • Place of Presentation: Groningen, the Netherlands
  • Year and Date: 2014-08-20 – 2014-08-23
• [Presentation] Insular activity during rectal distension associated with increased colonic response to CRH in IBS subjects. (2014)
  • Author(s): Kano M, Muratsubaki T, Yagihashi M, Morishita J, Tanaka Y, Ly HG, Dupont P, Van Oudenhove L, Kanazawa M, Fukudo S.
  • Organizer: 13th International Congress of Behavioral Medicine
  • Place of Presentation: Groningen, the Netherlands
  • Year and Date: 2014-08-20 – 2014-08-23
• [Presentation] Mindfulness reduces cue-induced food craving: an fMRI study. (2014)
  • Author(s): Murastubaki T, Sekiguchi A, Ishigaki Y, Sawada S, Kondo K, Kotozaki Y, Sasaki A, Morishita J, Kanazawa M, Katagiri H, Kawashima R, Kano M, Fukudo S.
  • Organizer: 13th International Congress of Behavioral Medicine
  • Place of Presentation: Groningen, the Netherlands
  • Year and Date: 2014-08-20 – 2014-08-23
• [Presentation] Update: 過敏性腸症候群の心身医学的治療． (2014)
  • Author(s): 金澤素、福土審．
  • Organizer: 第55回日本心身医学会総会
  • Place of Presentation: 千葉（幕張メッセ）
  • Year and Date: 2014-06-06 – 2014-06-07
  • Invited
• [Presentation] 過敏性腸症候群におけるHPA軸反応性と心理的要因の関連. (2014)
  • Author(s): 八木橋真央, 鹿野理子, 金澤素, 村椿智彦, 田中由佳里, 福土審．
  • Organizer: 第55回日本心身医学会総会
  • Place of Presentation: 千葉（幕張メッセ）
  • Year and Date: 2014-06-06 – 2014-06-07
• [Presentation] 過敏性腸症候群における副腎皮質刺激ホルモン放出ホルモン関連遺伝子. (2014)
  • Author(s): 佐々木彩加, 佐藤菜保子, 鹿野理子, 金澤素, 青木正志, 福土審．
  • Organizer: 第55回日本心身医学会総会
  • Place of Presentation: 千葉（幕張メッセ）
  • Year and Date: 2014-06-06 – 2014-06-07
• [Presentation] Phasic and tonic motility responses in the colorectum after peripheral administration of corticotropin-releasing hormone are exaggerated in patients with irritable bowel syndrome. (2014)
  • Author(s): Kanazawa M, Kano M, Muratsubaki T, Yagihashi M, Sasaki A, Tanaka Y, Morishita J, Fukudo S.
  • Organizer: The 115th Annual Meeting of American Gastroenterological Association (DDW2014)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Evidence of dopamine release during hypnotic analgesia under visceral stimulation in humans. (2014)
  • Author(s): Fukudo S, Morishita J, Watanabe S, Kawabata K, Ishizu N, Tanaka Y, Watanuki S, Hiraoka K, Kano M, Kanazawa M, Yanai K, Tashiro M.
  • Organizer: The 115th Annual Meeting of American Gastroenterological Association (DDW2014)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Increased colonic response to CRH in IBS subjects associates with insular activity during rectal distension. (2014)
  • Author(s): Kano M, Muratsubaki T, Yagihashi M, Morishita J, Tanaka Y, Ly HG, Dupont P, Van Oudenhove L, Kanazawa M, Fukudo S.
  • Organizer: The 115th Annual Meeting of American Gastroenterological Association (DDW2014)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Effect of 5-HT4 agonist mosapride on human gastric accommodation. (2014)
  • Author(s): Amano T, Ariga H, Yamato S, Kanazawa M, Fukudo S.
  • Organizer: The 115th Annual Meeting of American Gastroenterological Association (DDW2014)
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-05-03 – 2014-05-06
• [Presentation] Does camostat mesilate improve abdominal symptoms and visceral pain sensitivity in patients with irritable bowel syndrome (IBS)? (2014)
  • Author(s): Kanazawa M, Morishita J, Tanaka Y, Inooka K, Kano M, Hisamichi K, Mano N, Fukudo S.
  • Organizer: The 7th International Gastrointestinal Consensus Symposium (IGICS)
  • Place of Presentation: Fukushima, Japan
• [Presentation] Comparison of areement between reports of satisfactory relief and global improvement in patients With IBS: a cross-cultural study between the US and Japan. (2013)
  • Author(s): Kanazawa M, Whitehead WE, Palsson OS, Shinozaki M, Okuyama Y, Fukudo S.
  • Organizer: The 114th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: Orlando, USA
• [Presentation] Altered activation of cardiac sympathetic discharge and covariated brain region during colorectal distention with corticotropin-releasing hormone in irritable bowel syndrome. (2013)
  • Author(s): Tanaka Y, Morishita J, Kano M, Kanazawa M, Hamaguchi T, Tashiro M, Fukudo S.
  • Organizer: The 114th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: Orlando, USA
• [Presentation] 小児反復性腹痛の環境因子に関する検討 (2013)
  • Author(s): 金澤素、龍田希、渡辺諭史、清野静、遠藤由香、仲井邦彦、佐藤洋、福土審．
  • Organizer: 第54回日本心身医学会総会
  • Place of Presentation: 横浜
• [Presentation] 過敏性腸症候群における脳腸相関の病態 (2013)
  • Author(s): 金澤素、福土審．
  • Organizer: 第80回消化器心身医学研究会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 過敏性腸症候群患者に対するメシル酸カモスタットの効果 －内臓知覚ならびに大腸運動反応を中心として－. (2013)
  • Author(s): 金澤素、福土審.
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
• [Presentation] 過敏性腸症候群における“過敏性”症状の病態と治療. (2013)
  • Author(s): 金澤素.
  • Organizer: 第11回せとうち消化管運動研究会
  • Place of Presentation: 岡山
  • Invited
• [Presentation] Medical care for irritable bowel syndrome (IBS) in Japan compared to the US. (2012)
  • Author(s): Motoyori Kanazawa, William E Whitehead, Olafur S Palsson, Marsha J Turner, Masae Shinozaki, Yusuke Okuyama, Shin Fukudo.
  • Organizer: The 113th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: San Diego, USA
• [Presentation] Do protease inhibitors influence visceral pain sensitivity in patients with irritable bowel syndrome? (2012)
  • Author(s): Motoyori Kanazawa, Joe Morishita, Yukari Tanaka, Kyoko Inooka, Michiko Kano, Kanehiko Hisamichi, Nariyasu Mano, Shin Fukudo.
  • Organizer: The 113th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: San Diego, USA
• [Presentation] Visceral pain sensitivity to intraluminal distention in the rectum is heightened more than that in the descending colon in patients with irritable bowel syndrome (IBS). (2012)
  • Author(s): Motoyori Kanazawa, Olafur S Palsson, Marsha J Turner, Lisa M Gangarosa, Shin Fukudo, William E Whitehead.
  • Organizer: The 113th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: San Diego, USA
• [Presentation] Corticotropin-releasing hormone is associated with exaggerated brain activity and pituitary-adrenal response during colorectal distention in IBS. (2012)
  • Author(s): Yukari Tanaka, Joe Morishita, Motoyori Kanazawa, Toyohiro Hamaguchi, Manabu Tashiro, Shin Fukudo.
  • Organizer: The 113th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: San Diego, USA
• [Presentation] A stress-related peptide, urocortin 2 enhances gastric accommodation via nitrergic pathway in rats. (2012)
  • Author(s): Hajime Ariga, Tomofumi Amano, Ayako Kurematsu, Motoyori Kanazawa, Shin Fukudo, Shigeru Yamato.
  • Organizer: The 113th Annual Meeting of American Gastroenterological Association
  • Place of Presentation: San Diego, USA
• [Presentation] 日米の医療機関における過敏性腸症候群患者に対する治療比較. (2012)
  • Author(s): 金澤素、William E Whitehead、篠崎雅江、福土審.
  • Organizer: 第2回IBS研究会
  • Place of Presentation: 東京
• [Presentation] 日米の医療機関における過敏性腸症候群患者に対する治療比較. (2012)
  • Author(s): 金澤素、William E Whitehead、篠崎雅江、福土審.
  • Organizer: 第53回日本心身医学会総会
  • Place of Presentation: 鹿児島
• [Presentation] 過敏性腸症候群患者における直腸と下行結腸伸展刺激に対する内臓知覚過敏性の相違. (2012)
  • Author(s): 金澤素、Olafur S. Palsson、William E. Whitehead、福土審.
  • Organizer: 第14回日本神経消化器病学会
  • Place of Presentation: 大阪
• [Book] 自律神経機能検査（第5版） (2015)
  • Author(s): 金澤素, 福土審. 日本自律神経学会 編.
  • Total Pages: 748
  • Publisher: 文光堂
• [Book] 機能性消化管疾患診療ガイドライン2014 ‐過敏性腸症候群 (IBS)． (2014)
  • Author(s): 金澤素．日本消化器病学会 編．
  • Total Pages: 127
  • Publisher: 南江堂
• [Book] Functional and GI motility disorders. (2014)
  • Author(s): Fukudo S, Machida T, Endo Y, Shoji T, Kano M, Kanazawa M. In Quigley EMM, Hongo M, Fukudo S (eds).
  • Total Pages: 176
  • Publisher: Karger
• [Remarks] 東北大学病院心療内科ホームページ
  • URL: http://square.umin.ac.jp/thkpsm/index.htm