Therapeutic basis for sarcopenia control mediated by nuclear receptors

• Project/Area Number: 24590876
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: OGAWA SUMITO 東京大学, 医学部附属病院, 准教授 (20323579)
• Co-Investigator(Kenkyū-buntansha): OTA Hidetka 東京大学, 医学部附属病院, 特任講師 (20431869)
• Co-Investigator(Renkei-kenkyūsha): AKISHITA Masahiro 東京大学, 医学部附属病院, 教授 (00261975)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ビタミンD / 老化

Outline of Final Research Achievements

In this study, therapeutic basis for age-related sarcopenia control mediated by nuclear receptor ligand including vitamin D was investigated in vitro and in vivo, based on quantitative PCR and body composition analyses, respectively. It was suggested that vitamin D and leucine metabolite exert inflammatory control and improve skeletal muscle property, suggesting that nuclear receptor-mediated transcriptional control including vitamin D receptor might be effective for prevention and therapy of sarcopenia.